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Clinical Applications of Stochastic Dynamic Models of the Brain, Part I: A Primer

Roberts, JA; Friston, KJ; Breakspear, M; (2017) Clinical Applications of Stochastic Dynamic Models of the Brain, Part I: A Primer. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , 2 (3) pp. 216-224. 10.1016/j.bpsc.2017.01.010. Green open access

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Abstract

Biological phenomena arise through interactions between an organism's intrinsic dynamics and stochastic forces-random fluctuations due to external inputs, thermal energy, or other exogenous influences. Dynamic processes in the brain derive from neurophysiology and anatomical connectivity; stochastic effects arise through sensory fluctuations, brainstem discharges, and random microscopic states such as thermal noise. The dynamic evolution of systems composed of both dynamic and random effects can be studied with stochastic dynamic models (SDMs). This article, Part I of a two-part series, offers a primer of SDMs and their application to large-scale neural systems in health and disease. The companion article, Part II, reviews the application of SDMs to brain disorders. SDMs generate a distribution of dynamic states, which (we argue) represent ideal candidates for modeling how the brain represents states of the world. When augmented with variational methods for model inversion, SDMs represent a powerful means of inferring neuronal dynamics from functional neuroimaging data in health and disease. Together with deeper theoretical considerations, this work suggests that SDMs will play a unique and influential role in computational psychiatry, unifying empirical observations with models of perception and behavior.

Type: Article
Title: Clinical Applications of Stochastic Dynamic Models of the Brain, Part I: A Primer
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpsc.2017.01.010
Publisher version: http://dx.doi.org/10.1016/j.bpsc.2017.01.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Computational neuroscience, Computational psychiatry, Epilepsy, Mathematical modeling, Melancholia, Stochastic
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10057806
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