Oya, H;
Howard, MA;
Magnotta, VA;
Kruger, A;
Griffiths, TD;
Lemieux, L;
Carmichael, DW;
... Adolphs, R; + view all
(2017)
Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI.
Journal of Neuroscience Methods
, 277
pp. 101-112.
10.1016/j.jneumeth.2016.12.014.
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Abstract
BACKGROUND: Understanding brain function requires knowledge of how one brain region causally influences another. This information is difficult to obtain directly in the human brain, and is instead typically inferred from resting-state fMRI. NEW METHOD: Here, we demonstrate the safety and scientific promise of a novel and complementary approach: concurrent electrical stimulation and fMRI (es-fMRI) at 3 T in awake neurosurgical patients with implanted depth electrodes. RESULTS: We document the results of safety testing, actual experimental setup, and stimulation parameters, that safely and reliably evoke activation in distal structures through stimulation of amygdala, cingulate, or prefrontal cortex. We compare connectivity inferred from the evoked patterns of activation with that estimated from standard resting-state fMRI in the same patients: while connectivity patterns obtained with each approach are correlated, each method produces unique results. Response patterns were stable over the course of 11 min of es-fMRI runs. COMPARISON WITH EXISTING METHOD: es-fMRI in awake humans yields unique information about effective connectivity, complementing resting-state fMRI. Although our stimulations were below the level of inducing any apparent behavioral or perceptual effects, a next step would be to use es-fMRI to modulate task performances. This would reveal the acute network-level changes induced by the stimulation that mediate the behavioral and cognitive effects seen with brain stimulation. CONCLUSIONS: es-fMRI provides a novel and safe approach for mapping effective connectivity in the human brain in a clinical setting, and will inform treatments for psychiatric and neurodegenerative disorders that use deep brain stimulation.
| Type: | Article |
|---|---|
| Title: | Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jneumeth.2016.12.014 |
| Publisher version: | http://dx.doi.org/10.1016/j.jneumeth.2016.12.014 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Neurosciences & Neurology, Effective connectivity, Human, Electrical stimulation, Functional MRI, DBS, Amygdala, STATE FUNCTIONAL CONNECTIVITY, RESTING-STATE, PREFRONTAL CORTEX, DEFAULT NETWORK, AMYGDALA, DISEASE, MRI, MICROSTIMULATION, PATHWAYS, MACAQUE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10057703 |
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