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Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology

Kam, JH; Morgan, JE; Jeffery, G; (2016) Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology. Experimental Eye Research , 149 pp. 116-125. 10.1016/j.exer.2016.07.002. Green open access

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Abstract

Age-related macular degeneration (AMD) is the largest cause of visual loss in those over 60 years in the West and is a condition increasing in prevalence. Many diseases result from genetic/environmental interactions and 50% of AMD cases have an association with polymorphisms of the complement system including complement factor H. Here we explore interactions between genetic predisposition and environmental conditions in triggering retinal pathology in two groups of aged complement factor H knock out (Cfh−/−) mice. Mice were maintained over 9 months in either a conventional open environment or a barriered pathogen free environment. Open environment Cfh−/− mice had significant increases in subretinal macrophage numbers, inflammatory and stress responses and reduced photoreceptor numbers over mice kept in a pathogen free environment. Hence, environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh−/− mice.

Type: Article
Title: Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.exer.2016.07.002
Publisher version: http://dx.doi.org/10.1016/j.exer.2016.07.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ophthalmology, Age-related macular degeneration, Factor H, Pathogens, Inflammation, TUMOR-NECROSIS-FACTOR, C-REACTIVE PROTEIN, PIGMENT EPITHELIAL-CELLS, MACULAR DEGENERATION, ALZHEIMERS-DISEASE, AMYLOID-BETA, SYNAPTIC PLASTICITY, MOUSE RETINA, FACTOR-ALPHA, BACTERIAL-INFECTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10057585
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