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HIV treatment in pregnancy

Bailey, H; Zash, R; Rasi, V; Thorne, C; (2018) HIV treatment in pregnancy. The Lancet HIV , 5 (8) E457-E467. 10.1016/S2352-3018(18)30059-6. Green open access

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Abstract

Almost 25 years since antiretroviral therapy (ART) was first shown to prevent mother-to-child transmission of HIV, 76% of pregnant women living with HIV (over 1 million women) receive ART annually. This number is the result of successes in universal ART scale-up in low-income and middle-income countries. Despite unprecedented ART-related benefits to maternal and child health, challenges remain related to ART adherence, retention in care, and unequal access to ART. Implementation research is ongoing to understand and to address obstacles that lead to loss to follow-up. The biological mechanisms that underlie observed associations between antenatal ART and adverse outcomes in pregnancy and birth are not completely understood, with further research needed as well as strengthening of the systems to assess safety of antiretroviral drugs for the mother and HIV-exposed child. In the treat-all era, as duration of treatment and options for ART expand, pregnant women will remain a priority population for treatment optimisation to promote their health and that of their ART-exposed children.

Type: Article
Title: HIV treatment in pregnancy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2352-3018(18)30059-6
Publisher version: http://dx.doi.org/10.1016/S2352-3018(18)30059-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, TO-CHILD-TRANSMISSION, RANDOMIZED CONTROLLED-TRIAL, EXPOSED UNINFECTED INFANTS, FRENCH PERINATAL COHORT, ANTIRETROVIRAL THERAPY, INFECTED WOMEN, VIRAL SUPPRESSION, PRETERM DELIVERY, HIV-1-INFECTED WOMEN, POOLED ANALYSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10057524
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