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The same but different: cell intercalation as a driver of tissue deformation and fluidity

Tetley, RJ; Mao, Y; (2018) The same but different: cell intercalation as a driver of tissue deformation and fluidity. Philosophical Transactions B: Biological Sciences , 373 (1759) , Article 20170328. 10.1098/rstb.2017.0328. Green open access

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Abstract

The ability of cells to exchange neighbours, termed intercalation, is a key feature of epithelial tissues. Intercalation is predominantly associated with tissue deformations that drive morphogenesis. More recently, however, intercalation that is not associated with large-scale tissue deformations has been described both during animal development and in mature epithelial tissues. This latter form of intercalation appears to contribute to an emerging phenomenon that we refer to as tissue fluidity—the ability of cells to exchange neighbours without changing the overall dimensions of the tissue. Here, we discuss the contribution of junctional dynamics to intercalation governing both morphogenesis and tissue fluidity. In particular, we focus on the relative roles of junctional contractility and cell–cell adhesion as the driving forces behind intercalation. These two contributors to junctional mechanics can be used to simulate cellular intercalation in mechanical computational models, to test how junctional cell behaviours might regulate tissue fluidity and contribute to the maintenance of tissue integrity and the onset of disease.

Type: Article
Title: The same but different: cell intercalation as a driver of tissue deformation and fluidity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rstb.2017.0328
Publisher version: http://doi.org/10.1098/rstb.2017.0328
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: intercalation, morphogenesis, fluidity, mechanics, vertex model
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10057454
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