Pietrusz, A; Scalco, RS; Quinlivan, R; (2018) Resistance Exercise Training in McArdle Disease: Myth or Reality? Case Reports in Neurological Medicine , 2018 , Article 9658251. 10.1155/2018/9658251.

Text 2018_Pietrusz et al_Case Report_Resistance Exercise Training in McArdle Disease_Myth or Reality_9658251.pdf - Published Version Download (1MB)

Abstract

McArdle disease is a metabolic myopathy mainly characterised by symptom onset during physical activities or isometric muscle contraction. Resistance (also termed strength) training is a type of physical exercise focusing on the use of resistance (e.g., lifing weights) to induce muscular contraction, which builds muscle mass and strength. Historically people with McArdle disease were advised to avoid resistance exercises and any other form of physical activity involving high mechanical loads such as prolonged isometric contraction. Paradoxically, a clinical trial exploring the benefts of strength training in this patient population was published. Te theory supporting strength training relied on the use of the ATP molecule and the creatine phosphate (ATPphosphocreatine system) as energy sources for skeletal muscles. Here, we report two patients with McArdle disease who performed weight training at local gyms. A single set of repetitions lasted for maximum 10 seconds with minimum of 30 seconds of rest period in between sets of exercises. Benefts of this type of training included improvement in quality of life and amelioration of McArdle disease symptoms. We provide further safety evidence of this type of exercise in people with McArdle disease. We emphasise the importance of using a specifc protocol developed for people afected by this condition.

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