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Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

Coleman, JRI; Bryois, J; Gaspar, HA; Jansen, PR; Savage, JE; Skene, N; Plomin, R; ... Breen, G; + view all (2019) Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Molecular Psychiatry , 24 pp. 182-197. 10.1038/s41380-018-0040-6. Green open access

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Abstract

Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78,308) were meta-analyzed with a study comparing 1247 individuals with mean IQ ~170 to 8185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

Type: Article
Title: Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41380-018-0040-6
Publisher version: https://doi.org/10.1038/s41380-018-0040-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cell biology, Genetics, Neuroscience
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10057089
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