Thompson, N;
Isenberg, DA;
Jury, EC;
Ciurtin, C;
(2016)
Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome.
Rheumatology
, 55
(9)
pp. 1548-1555.
10.1093/rheumatology/kev420.
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Abstract
SS is an autoimmune condition characterized by exocrine gland destruction, autoantibody production, immune complex deposition and systemic complications associated with lymphocytic infiltration of many organs. Genetic, environmental and viral factors play a role in disease aetiology, however, the exact mechanisms driving the immunopathogenesis of SS remain uncertain. Here we discuss a role for B cell activating factor (BAFF), whereby B cell hyperactivity and increased BAFF secretion observed in patients and animal models of the disease can be explained by the altered expression of cell-specific BAFF/BAFF receptor (BAFF-R) variants in several immune cell types. Understanding the role of BAFF/BAFF-R heterogeneity in SS pathogenesis could help to facilitate new treatment strategies for patients.
Type: | Article |
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Title: | Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1093/rheumatology/kev420 |
Publisher version: | http://dx.doi.org/10.1093/rheumatology/kev420 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions |
Keywords: | Rheumatology, B cell activating factor (BAFF), BAFF receptor, Sjogren's syndrome, CELL-ACTIVATING FACTOR, FACTOR FAMILY BAFF, B-CELL, TRANSGENIC MICE, LIPID RAFTS, SPLICE ISOFORM, DELTA-BAFF, SURVIVAL, MECHANISMS, APRIL |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
URI: | https://discovery.ucl.ac.uk/id/eprint/10057028 |
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