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Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome

Thompson, N; Isenberg, DA; Jury, EC; Ciurtin, C; (2016) Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome. Rheumatology , 55 (9) pp. 1548-1555. 10.1093/rheumatology/kev420. Green open access

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Abstract

SS is an autoimmune condition characterized by exocrine gland destruction, autoantibody production, immune complex deposition and systemic complications associated with lymphocytic infiltration of many organs. Genetic, environmental and viral factors play a role in disease aetiology, however, the exact mechanisms driving the immunopathogenesis of SS remain uncertain. Here we discuss a role for B cell activating factor (BAFF), whereby B cell hyperactivity and increased BAFF secretion observed in patients and animal models of the disease can be explained by the altered expression of cell-specific BAFF/BAFF receptor (BAFF-R) variants in several immune cell types. Understanding the role of BAFF/BAFF-R heterogeneity in SS pathogenesis could help to facilitate new treatment strategies for patients.

Type: Article
Title: Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kev420
Publisher version: http://dx.doi.org/10.1093/rheumatology/kev420
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions
Keywords: Rheumatology, B cell activating factor (BAFF), BAFF receptor, Sjogren's syndrome, CELL-ACTIVATING FACTOR, FACTOR FAMILY BAFF, B-CELL, TRANSGENIC MICE, LIPID RAFTS, SPLICE ISOFORM, DELTA-BAFF, SURVIVAL, MECHANISMS, APRIL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10057028
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