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Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Miyamoto, K; Nguyen, KT; Allen, GE; Jullien, J; Kumar, D; Otani, T; Bradshaw, CR; ... Gurdon, JB; + view all (2018) Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes. Cell Reports , 24 (2) pp. 304-311. 10.1016/j.celrep.2018.06.030. Green open access

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Abstract

Miyamoto et al. show genome-wide changes in chromatin accessibility during transcriptional reprogramming in oocytes using the frog nuclear transfer system. They demonstrate that donor cell chromatin states affect transcriptional reprogramming and changes in open chromatin during reprogramming are associated with specific transcription factors.

Type: Article
Title: Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2018.06.030
Publisher version: http://dx.doi.org/10.1016/j.celrep.2018.06.030
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: open chromatin, transcriptional activation, reprogramming, nuclear transfer
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10056812
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