Theisen, U;
Hey, S;
Hennig, CD;
Schnabel, R;
Köster, RW;
(2018)
Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration.
Communicative and Integrative Biology
, 11
(3)
, Article e1493324. 10.1080/19420889.2018.1493324.
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Abstract
Various neurotransmitters influence neuronal migration in the developing zebrafish hindbrain. Migrating tegmental hindbrain nuclei neurons (THNs) are governed by depolarizing neurotransmitters (acetylcholine and glutamate), and glycine. In mature neurons, glycine binds to its receptor to hyperpolarize cells. This effect depends on the co-expression of the solute carrier KCC2. Immature precursors, however, typically express NKCC1 instead of KCC2, leading to membrane depolarization upon glycine receptor activation. As neuronal migration occurs in neurons after leaving the cell cycle and before terminal differentiation, we hypothesized that the switch from NKCC1 to KCC2 expression could alter the effect of glycine on THN migration. We tested this notion using in vivo cell tracking, overexpression of glycine receptor mutations and whole mount in situ hybridization. We summarize our findings in a speculative model, combining developmental age, glycine receptor strength and solute carrier expression to describe the effect of glycine on the migration of THNs.
| Type: | Article |
|---|---|
| Title: | Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/19420889.2018.1493324 |
| Publisher version: | http://doi.org/10.1080/19420889.2018.1493324 |
| Language: | English |
| Additional information: | Copyright © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Neuronal migration; neurotransmitters; glycine; glycine receptor alpha 1; NKCC1; zebrafish |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10056761 |
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