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Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis

Fidler, K; Foster, C; Lim, EJ; Patel, A; Welch, S; Menson, E; Klein, N; ... Collaborative HIV Paediatric Study (CHIPS) Steering Committee; + view all (2019) Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis. Pediatric Infectious Disease Journal , 38 (2) pp. 146-148. 10.1097/INF.0000000000002143. Green open access

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Abstract

We assessed HIV antibody prevalence in children with perinatally-acquired HIV (PaHIV) in England. 18%(10/55) of those starting combination antiretroviral therapy (cART) <6 months of age were seronegative, and had lower viral load at diagnosis and cART start, and fewer viral rebounds, than 45/55 seropositives. Implications for patient selection for HIV cure research, and interpretation of routine antibody testing, are discussed.

Type: Article
Title: Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/INF.0000000000002143
Publisher version: http://dx.doi.org/10.1097/INF.0000000000002143
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: HIV, children, HIV antibody, seronegativity, seroreversion
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10056628
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