Fidler, K;
Foster, C;
Lim, EJ;
Patel, A;
Welch, S;
Menson, E;
Klein, N;
... Collaborative HIV Paediatric Study (CHIPS) Steering Committee; + view all
(2019)
Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis.
Pediatric Infectious Disease Journal
, 38
(2)
pp. 146-148.
10.1097/INF.0000000000002143.
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Abstract
We assessed HIV antibody prevalence in children with perinatally-acquired HIV (PaHIV) in England. 18%(10/55) of those starting combination antiretroviral therapy (cART) <6 months of age were seronegative, and had lower viral load at diagnosis and cART start, and fewer viral rebounds, than 45/55 seropositives. Implications for patient selection for HIV cure research, and interpretation of routine antibody testing, are discussed.
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