Matias, D;
Balca-Silva, J;
da Graca, GC;
Wanjiru, CM;
Macharia, LW;
Nascimento, CP;
Roque, NR;
... Moura-Neto, V; + view all
(2018)
Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors.
Frontiers in Cellular Neuroscience
, 12
, Article 235. 10.3389/fncel.2018.00235.
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Abstract
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of the interaction between microglial/astrocytes cells and GB may constitute a potential therapeutic target to overcome tumor malignancy. In the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes–GB interactions, which is particularly the alterations that occur in the cell’s extracellular matrix and the cytoskeleton. We overview the cytokines, chemokines, neurotrophic, morphogenic, metabolic factors, and non-coding RNAs actions crucial to these interactions. We have also discussed the most recent studies regarding the mechanisms of transportation and communication between microglial/astrocytes – GB cells, namely through the ABC transporters or by extracellular vesicles. Lastly, we highlight the therapeutic challenges and improvements regarding the crosstalk between these glial cells and GB.
| Type: | Article |
|---|---|
| Title: | Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fncel.2018.00235 |
| Publisher version: | https://doi.org/10.3389/fncel.2018.00235 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, glioblastoma, astrocytes, microglia, crosstalk, cytokines, molecular mechanisms, microenvironmental factors, communication mechanisms, TUMOR-ASSOCIATED MACROPHAGES, CENTRAL-NERVOUS-SYSTEM, GROWTH-FACTOR-BETA, HIGH-GRADE GLIOMA, TO-MESENCHYMAL TRANSITION, SQUAMOUS-CELL CARCINOMA, INNATE IMMUNE-RESPONSE, CNTF RECEPTOR-ALPHA, LONG NONCODING RNAS, BREAST-CANCER CELLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10056582 |
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