Sanders, SJ;
Campbell, AJ;
Cottrell, JR;
Moller, RS;
Wagner, FF;
Auldridge, AL;
Bernier, RA;
... Bender, KJ; + view all
(2018)
Progress in Understanding and Treating SCN2A-Mediated Disorders.
Trends in Neurosciences
, 41
(7)
pp. 442-456.
10.1016/j.tins.2018.03.011.
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Abstract
Advances in gene discovery for neurodevelopmental disorders have identified SCN2A dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual disability. SCN2A encodes the neuronal sodium channel NaV1.2. Functional assays demonstrate strong correlation between genotype and phenotype. This insight can help guide therapeutic decisions and raises the possibility that ligands that selectively enhance or diminish channel function may improve symptoms. The well-defined function of sodium channels makes SCN2A an important test case for investigating the neurobiology of neurodevelopmental disorders more generally. Here, we discuss the progress made, through the concerted efforts of a diverse group of academic and industry scientists as well as policy advocates, in understanding and treating SCN2A-related disorders.
Type: | Article |
---|---|
Title: | Progress in Understanding and Treating SCN2A-Mediated Disorders |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.tins.2018.03.011 |
Publisher version: | http://doi.org/10.1016/j.tins.2018.03.011 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
URI: | https://discovery.ucl.ac.uk/id/eprint/10056463 |
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