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After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly

Darvishian, M; Gefenaite, G; Turner, RM; Pechlivanoglou, P; Van der Hoek, W; Van den Heuvel, ER; Hak, E; (2014) After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. Journal of Clinical Epidemiology , 67 (7) pp. 734-744. 10.1016/j.jclinepi.2014.02.009. Green open access

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Abstract

Objective To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older. Study Design and Setting Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hospitalization from influenza and/or pneumonia, and all-cause mortality were study outcomes. Potential biases were identified using bias checklists. The magnitude and uncertainty of biases were assessed by expert opinion. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random effects model. Results After incorporating biases, overall effect estimates regressed slightly toward no effect, with the largest relative difference between conventional and bias-adjusted ORs for laboratory-confirmed influenza (OR, 0.18; 95% CI: 0.01, 3.00 vs. OR, 0.23; 95% CI: 0.03, 2.04). In most of the studies, CIs widened reflecting uncertainties about the biases. The between-study heterogeneity reduced considerably with the largest reduction for all-cause mortality (I2 = 4%, P = 0.39 vs. I2 = 91%, P < 0.01). Conclusion This case study showed that after addressing potential biases influenza vaccine was still estimated effective in preventing hospitalization from influenza and/or pneumonia and all-cause mortality. Increasing the number of assessors and incorporating empirical evidence might improve the new bias-adjustment method.

Type: Article
Title: After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jclinepi.2014.02.009
Publisher version: https://doi.org/10.1016/j.jclinepi.2014.02.009
Language: English
Additional information: Copyright © 2014 The Authors. Published by Elsevier Inc. Open access under CC BY-NC-ND license
Keywords: Meta-analysis, Bias adjustment, Observational studies, Seasonal influenza, Vaccination, Community-dwelling elderly
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10056395
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