UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Ubiquitination at the mitochondria in neuronal health and disease

Covill-Cooke, C; Howden, JH; Birsa, N; Kittler, JT; (2018) Ubiquitination at the mitochondria in neuronal health and disease. Neurochemistry International , 117 pp. 55-64. 10.1016/j.neuint.2017.07.003. Green open access

[thumbnail of Ubiquitination at the Mitochondria in Neuronal Health and Disease.pdf]
Preview
Text
Ubiquitination at the Mitochondria in Neuronal Health and Disease.pdf - Accepted Version

Download (486kB) | Preview

Abstract

The preservation of mitochondrial function is of particular importance in neurons given the high energy requirements of action potential propagation and synaptic transmission. Indeed, disruptions in mitochondrial dynamics and quality control are linked to cellular pathology in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Here, we will discuss the role of ubiquitination by the E3 ligases: Parkin, MARCH5 and Mul1, and how they regulate mitochondrial homeostasis. Furthermore, given the role of Parkin and Mul1 in the formation of mitochondria-derived vesicles we give an overview of this area of mitochondrial homeostasis. We highlight how through the activity of these enzymes and MDV formation, multiple facets of mitochondrial biology can be regulated, ensuring the functionality of the mitochondrial network thus preserving neuronal health.

Type: Article
Title: Ubiquitination at the mitochondria in neuronal health and disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuint.2017.07.003
Publisher version: https://doi.org/10.1016/j.neuint.2017.07.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Mitochondria, Ubiquitin, Neurodegeneration, E3 ligase, Mitochondria-derived vesicles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10056131
Downloads since deposit
664Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item