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Circulating Tumour DNA in Muscle-Invasive Bladder Cancer

Tan, MP; Attard, G; Huddart, RA; (2018) Circulating Tumour DNA in Muscle-Invasive Bladder Cancer. International Journal of Molecular Sciences , 19 (9) , Article 2568. 10.3390/ijms19092568. Green open access

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Abstract

Circulating tumour DNA (ctDNA) is an attractive tool in cancer research, offering many advantages over tissue samples obtained using traditional biopsy methods. There has been increasing interest in its application to muscle-invasive bladder cancer (MIBC), which is recognised to be a heterogeneous disease with overall poor prognosis. Using a range of platforms, studies have shown that ctDNA is detectable in MIBC and may be a useful biomarker in monitoring disease status and guiding treatment decisions in MIBC patients. Currently, with no such predictive or prognostic biomarkers in clinical practice to guide treatment strategy, there is a real unmet need for a personalised medicine approach in MIBC, and ctDNA offers an exciting avenue through which to pursue this goal. In this article, we present an overview of work to date on ctDNA in MIBC, and discuss the inherent challenges present as well as the potential future clinical applications.

Type: Article
Title: Circulating Tumour DNA in Muscle-Invasive Bladder Cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms19092568
Publisher version: https://doi.org/10.3390/ijms19092568
Language: English
Additional information: © 2018 by the Authors. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: circulating tumour DNA (ctDNA), muscle-invasive bladder cancer (MIBC), biomarker
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10056088
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