Baxendale, S;
Thompson, P;
(2016)
The new approach to epilepsy classification: Cognition and behavior in adult epilepsy syndromes.
Epilepsy & Behavior
, 64
pp. 253-256.
10.1016/j.yebeh.2016.09.003.
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Abstract
The revised terminology and concepts for the organization of seizures and epilepsy proposed by the ILAE Commission on Classification and Terminology in 2010 allows for a number of new opportunities in the study of cognition and behavior in adults. This review examines the literature that has looked for behavioral and cognitive correlates of the newly recognized genetic epilepsies in adults. While some studies report clear cognitive phenotypes associated with specific genetic mutations in adults with epilepsy, others report remarkable clinical heterogeneity. In the second part of this review, we discuss some of the factors that may influence the findings in this literature. Cognitive function is the product of both genetic and environmental influences. Neuropsychological phenotypes under direct genetic influence may be wider and more subtle than specific deficits within discreet cognitive domains and may be reflected in broader, multidimensional measures of cognitive function than those tapped by scores on standardized tests of function. Future studies must be carefully designed to reflect these factors. It is also imperative that studies with negative findings are assigned as much value as those with positive results and published accordingly.
| Type: | Article |
|---|---|
| Title: | The new approach to epilepsy classification: Cognition and behavior in adult epilepsy syndromes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.yebeh.2016.09.003 |
| Publisher version: | https://doi.org/10.1016/j.yebeh.2016.09.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Clinical Neurology, Psychiatry, Neurosciences & Neurology, Epilepsy classification, Neuropsychology, Memory, Review, Cognitive Phenotype, TEMPORAL-LOBE EPILEPSY, TUBEROUS SCLEROSIS COMPLEX, HIPPOCAMPAL NEURON LOSS, DRAVET SYNDROME, VERBAL MEMORY, PHENOTYPES, ORGANIZATION, TERMINOLOGY, LOBECTOMY, SEIZURES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10056022 |
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