Chen, J-C;
Macerollo, A;
Sadnicka, A;
Lu, M-K;
Tsai, C-H;
Korlipara, P;
Bhatia, K;
... Edwards, MJ; + view all
(2018)
Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity.
Clinical Neurophysiology
, 129
(9)
pp. 1947-1954.
10.1016/j.clinph.2018.05.028.
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Abstract
OBJECTIVE: Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare “odd ball” stimulus. METHODS: We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls. RESULTS: We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρ₁ = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: −1.0 µV ± 0.3, p < 0.00, t = −3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: −0.2 µV ± 0.2, p = 0.24, t = −1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold.CONCLUSION: These results suggest that pre-attentive error/deviant detection, specifically in the somatosensory domain, is abnormal in dystonia. This could underlie some previously reported electrophysiological and psychophysical abnormalities of somatosensory integration in dystonia. SIGNIFICANCE: One could hypothesize a deficit in pre-conscious orientation towards potentially salient signals might lead to a more conservative threshold for decision-making in dystonia.
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