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Glia relay differentiation cues to coordinate neuronal development in Drosophila

Fernandes, VM; Chen, Z; Rossi, AM; Zipfel, J; Desplan, C; (2017) Glia relay differentiation cues to coordinate neuronal development in Drosophila. Science , 357 (6354) pp. 886-891. 10.1126/science.aan3174. Green open access

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Abstract

Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation cue, epidermal growth factor (EGF). We find that communication between photoreceptors and lamina cells requires a signaling relay through glia. In response to photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation. Our study identifies a role for glia in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation.

Type: Article
Title: Glia relay differentiation cues to coordinate neuronal development in Drosophila
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aan3174
Publisher version: http://dx.doi.org/10.1126/science.aan3174
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animals, Drosophila Proteins, Drosophila melanogaster, Insulin, Membrane Proteins, Mutation, Neurogenesis, Neuroglia, Optic Lobe, Nonmammalian, Photoreceptor Cells, Invertebrate, Receptor, Epidermal Growth Factor, Receptors, Invertebrate Peptide, Serine Endopeptidases, Signal Transduction
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10055828
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