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Developing Whole-body Magnetic Resonance Imaging Biomarkers for the Assessment of Haematological Malignancies

Latifoltojar, Arash; (2018) Developing Whole-body Magnetic Resonance Imaging Biomarkers for the Assessment of Haematological Malignancies. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Whole body magnetic resonance imaging (WB-MRI) is being recognised as an alternative to conventional computed tomography, isotope bone scan and PET-CT scan. Advances in MR imaging have enabled sophisticated whole body protocols interrogating and imaging different facets of tumour biology. Furthermore, these multi-sequence WB-MRI protocols can be applied within patient friendly examination times. Qualitative and quantitative evaluation of WB-MRI examinations can now readily be performed, and form the focus of ongoing research into clinical utility for disease staging and response assessment. Quantitative WB-MRI research has mainly concentrated on diffusion weighted imaging (DWI) derived apparent diffusion coefficient (ADC), a parameter broadly representative of tumour cellularity. This thesis focuses on evaluating WB-MRI in the setting of lymphoma and multiple myeloma (haematological malignancies) through a series of translational imaging biomarker developmental studies. The first study retrospectively evaluates the diagnostic accuracy of WB-MRI (performed at 1.5 T) for the staging of paediatric Hodgkin’s lymphoma (HL) (Chapter 3) and determines ADC quantitative thresholds for disease detection (Chapter 4). Following this, a clinical trial of WB-MRI with prospective application of quantitative ADC thresholds for staging and response assessment of paediatric HL is described (Chapter 5). The final 3 chapters describe the WB-MRI studies conducted at 3.0 T – exploring the potential value of higher field strengths, and the reliability of novel quantitative imaging biomarkers for the diagnosis and response assessment of lymphoma and multiple myeloma.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Developing Whole-body Magnetic Resonance Imaging Biomarkers for the Assessment of Haematological Malignancies
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10055800
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