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An optical sensor to monitor dynamics of extracellular glycine

Rusakov, DA; (2018) An optical sensor to monitor dynamics of extracellular glycine. Nature Chemical Biology , 14 (9) pp. 835-836. 10.1038/s41589-018-0123-3. Green open access

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Abstract

A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.

Type: Article
Title: An optical sensor to monitor dynamics of extracellular glycine
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41589-018-0123-3
Publisher version: https://doi.org/10.1038/s41589-018-0123-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10055778
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