UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size: a biomechanical hypothesis of post-lensectomy glaucoma

Daniel, MC; Dubis, AM; Theodorou, M; Quartilho, A; Adams, G; Brookes, J; Papadopoulos, M; ... Dahlmann-Noor, AH; + view all (2018) Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size: a biomechanical hypothesis of post-lensectomy glaucoma. Ophthalmology 10.1016/j.ophtha.2018.08.031. (In press). Green open access

[thumbnail of Khaw_Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size_AAM.pdf]
Preview
Text
Khaw_Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size_AAM.pdf - Accepted Version

Download (5MB) | Preview

Abstract

OBJECTIVE: To compare Schlemm canal (SC) and trabecular meshwork (TM) in children with healthy eyes and those with and without glaucoma after lensectomy. DESIGN: Cross-sectional observational study. PARTICIPANTS: Fifty children age 4 to 16 years with healthy eyes and 48 children post lensectomy (124 healthy and 72 post-lensectomy eyes). METHODS: /Interventions: Anterior segment optical coherence tomography (AS-OCT, Tomey Casia) of the nasal iridocorneal angle, at two levels of accommodative effort (2.5D, 15D). For each parameter and state of accommodation, a random-effects model was fitted to estimate differences between healthy eyes and eyes with history of lensectomy. MAIN OUTCOME MEASURES: Dimensions of SC and TM; conventional AS-OCT irido-corneal angle (ICA) measurements. RESULTS: The horizontal diameter of SC and its cross-sectional area (SC-CSA) are significantly smaller in post-lensectomy than in healthy eyes. Accommodative effort increases SC size in healthy, but not in post-lensectomy eyes. CONCLUSIONS: Lensectomy is associated with a reduction in SC size and a loss of physiological SC dilatation during accommodative effort, which may reflect a reduction in outflow facility and contribute to the development of post-lensectomy glaucoma.

Type: Article
Title: Childhood lensectomy is associated with static and dynamic reduction in Schlemm canal size: a biomechanical hypothesis of post-lensectomy glaucoma
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ophtha.2018.08.031
Publisher version: https://doi.org/10.1016/j.ophtha.2018.08.031
Language: English
Additional information: © 2018 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology. This is an Open Access article distributed under the terms of the Creative Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Child, Adolescent, Congenital, Hereditary and Neonatal Diseases and Abnormalities, Cataract, Glaucoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10055736
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item