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All-optical dual photoacoustic and optical coherence tomography intravascular probe

Mathews, SJ; Little, C; Loder, CD; Rakhit, RD; Xia, W; Zhang, EZ; Beard, PC; ... Desjardins, AE; + view all (2018) All-optical dual photoacoustic and optical coherence tomography intravascular probe. Photoacoustics , 11 pp. 65-70. 10.1016/j.pacs.2018.07.002. Green open access

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Abstract

Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 μm to 40 μm; the axial resolution was consistently in the vicinity of 45 μm. We demonstrated the clinical potential of the probe with 2-D circumferential PA and OCT imaging, and with multispectral PA imaging.

Type: Article
Title: All-optical dual photoacoustic and optical coherence tomography intravascular probe
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pacs.2018.07.002
Publisher version: http://dx.doi.org/10.1016/j.pacs.2018.07.002
Language: English
Additional information: © 2018 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Keywords: All-optical intravascular catheter, Endoscopic imaging, Fiber optic ultrasound sensor, Intravascular photoacoustic imaging, Optical coherence tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10055624
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