UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa

Majonga, ED; Rehman, AM; McHugh, G; Mujuru, HA; Nathoo, K; Patel, MS; Munyati, S; ... Ferrand, RA; + view all (2017) Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa. International Journal of Cardiology , 248 pp. 409-413. 10.1016/j.ijcard.2017.06.109. Green open access

[thumbnail of Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa.pdf]
Preview
Text
Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa.pdf - Published Version

Download (514kB) | Preview

Abstract

BACKGROUND: Echocardiographic reference ranges are important to identify abnormalities of cardiac dimensions. Reference ranges for children in sub-Saharan Africa have not been established. The aim of this study was to establish echocardiographic z-score references for Black children in sub-Saharan Africa. METHODS: 282 healthy subjects aged 6–16 years (143 [51%] males) with no known history of cardiac disease were enrolled in the study in Harare, Zimbabwe between 2014 and 2016. Standard M-mode echocardiography was performed and nine cardiac chamber dimensions were obtained. Two non-linear statistical models (gamma weighted model and cubic polynomial model) were tested on the data and the best fitting model was used to calculate z-scores of these cardiac chamber measures. The reference ranges are presented on scatter plots against BSA. RESULTS: Normative data for the following cardiac measures were obtained and z-scores calculated: right ventricular diameter at end diastole (RVEDD); left ventricular diameter at end diastole (LVEDD) and systole (LVESD); interventricular septal wall thickness at end diastole (IVSd) and systole (IVSs); left ventricular posterior wall thickness at end diastole (LVPWd) and systole (LVPWs); left atrium diameter at end systole (LA) and tricuspid annular plane systolic excursion (TAPSE). Girls had higher values for BMI and heart rate than boys (p = 0.048 and p = 0.001, respectively). Mean interventricular septal and left ventricular posterior walls thickness was higher than published normal values in predominantly Caucasian populations. CONCLUSION: These are the first echocardiographic reference ranges for children from sub Saharan Africa and will allow accurate assessment of cardiac dimensions in clinical practice.

Type: Article
Title: Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijcard.2017.06.109
Publisher version: http://dx.doi.org/10.1016/j.ijcard.2017.06.109
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Echocardiography, Reference ranges, Z-scores, Children, Africa, PLANE SYSTOLIC EXCURSION, HEALTHY TURKISH CHILDREN, REFERENCE VALUES, HEART-DISEASE, BODY-SIZE, Z-SCORES, CHAMBER, INFANTS, MASS, AGE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/10055498
Downloads since deposit
97Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item