UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells

Qin, L; Yan, P; Xie, C; Huang, J; Ren, Z; Li, X; Best, S; ... Han, G; + view all (2018) Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells. Nanoscale , 10 (28) pp. 13432-13442. 10.1039/c8nr03802c. Green open access

[img]
Preview
Text
Gold nanorods-assembled ZGOC nanofibers for LED-amplified gene silencing in cancer cells.pdf - Accepted version

Download (1MB) | Preview

Abstract

Nanoparticles are now commonly used as non-viral gene vectors for RNA interference (RNAi) in cancer therapy but suffer from low targeting efficiency in situ. Meanwhile, localized drug delivery systems do not offer the effective capability for intracellular gene transportation. We describe here the design and synthesis of a localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers. This composite system offers the potential for a LED-induced mild photothermal effect which enhances the phagocytosis of Au NRs carrying siRNA and the subsequent release of siRNA in the cytoplasm. Both phenomena amplify the gene silencing effect and consequently offer the potential for a superior therapeutic outcome.

Type: Article
Title: Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c8nr03802c
Publisher version: https://doi.org/10.1039/c8nr03802c
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Chemistry, Science & Technology - Other Topics, Materials Science, Physics, INFRARED PERSISTENT LUMINESCENCE, SMALL INTERFERING RNA, DRUG-DELIVERY, IN-VIVO, PHOTOTHERMAL THERAPY, PHOTODYNAMIC THERAPY, ANTICANCER THERAPY, SIRNA DELIVERY, NANOPARTICLES, THERAPEUTICS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10055387
Downloads since deposit
5Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item