Qin, L;
Yan, P;
Xie, C;
Huang, J;
Ren, Z;
Li, X;
Best, S;
... Han, G; + view all
(2018)
Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells.
Nanoscale
, 10
(28)
pp. 13432-13442.
10.1039/c8nr03802c.
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Gold nanorods-assembled ZGOC nanofibers for LED-amplified gene silencing in cancer cells.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Nanoparticles are now commonly used as non-viral gene vectors for RNA interference (RNAi) in cancer therapy but suffer from low targeting efficiency in situ. Meanwhile, localized drug delivery systems do not offer the effective capability for intracellular gene transportation. We describe here the design and synthesis of a localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers. This composite system offers the potential for a LED-induced mild photothermal effect which enhances the phagocytosis of Au NRs carrying siRNA and the subsequent release of siRNA in the cytoplasm. Both phenomena amplify the gene silencing effect and consequently offer the potential for a superior therapeutic outcome.
| Type: | Article |
|---|---|
| Title: | Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c8nr03802c |
| Publisher version: | https://doi.org/10.1039/c8nr03802c |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Chemistry, Science & Technology - Other Topics, Materials Science, Physics, INFRARED PERSISTENT LUMINESCENCE, SMALL INTERFERING RNA, DRUG-DELIVERY, IN-VIVO, PHOTOTHERMAL THERAPY, PHOTODYNAMIC THERAPY, ANTICANCER THERAPY, SIRNA DELIVERY, NANOPARTICLES, THERAPEUTICS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055387 |
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