Borim, FSA;
Alexandre, TDS;
Neri, AL;
Máximo, RDO;
Silva, MF;
De Oliveira, C;
(2019)
Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability.
Journal of the American Medical Directors Association
, 20
(1)
pp. 47-52.
10.1016/j.jamda.2018.06.006.
Preview |
Text
De Oliveira_Revised Manuscript_Cesar.pdf - Accepted Version Download (275kB) | Preview |
Abstract
BACKGROUND AND OBJECTIVE: There is little epidemiologic evidence considering the combined effect of dynapenia and low 25-hydroxyvitamin D [25 (OH) D] on incident disability. Our aim was to investigate whether the combination of dynapenia and low 25 (OH) D serum levels increases the risk of activities of daily living (ADL) incident disability. DESIGN: Prospective cohort study. SETTINGS: English Longitudinal Study of Aging. PARTICIPANTS: A total of 4630 community-dwelling adults aged 50 years and older without ADL disability at baseline. MEASUREMENTS: The baseline sample was categorized into 4 groups (ie, nondynapenic/normal 25 (OH) D, low 25 (OH) D only, dynapenic only, and dynapenic/low 25 (OH) D according to their handgrip strength (<26 kg for men and <16 kg for women) and 25 (OH) D (≤50 nmol/L). The outcome was the presence of any ADL disability 2 years after baseline according to the modified Katz Index. Incidence rate ratios (IRRs) adjusted by sociodemographic, behavioral, and clinical characteristics were estimated using Poisson regression. RESULTS: The fully adjusted model showed that older adults with dynapenia only and those with lower serum levels of 25 (OH) D combined with dynapenia had higher incident ADL disability risk compared with nondynapenic and those with normal serum levels of 25 (OH) D. The IRRs for lower 25 (OH) D serum levels combined with dynapenia were higher than for dynapenia only, however, the confidence intervals (CIs) showed similar effect for these 2 groups. The IRRs were 1.31 for low 25(OH) D only (95% CI 0.99-1.74), 1.77 for dynapenia only (95% CI 1.08-2.88), and 1.94 for combined dynapenia and low 25(OH)D (95% CI 1.28-2.94). CONCLUSIONS: Dynapenia only and dynapenia combined with low 25 (OH) D serum levels were important risk factors for ADL disability in middle-aged individuals and older adults in 2 years of follow-up.
| Type: | Article |
|---|---|
| Title: | Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jamda.2018.06.006 |
| Publisher version: | https://doi.org/10.1016/j.jamda.2018.06.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 25(OH) D, Handgrip, muscle strength, vitamin D |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10055293 |
Archive Staff Only
 |
View Item |
