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Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer

Bates, A; Miles, K; (2017) Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer. European Radiology , 27 (12) pp. 5290-5298. 10.1007/s00330-017-4877-x. Green open access

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Abstract

OBJECTIVES: To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR. METHODS: Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at <5%. RESULTS: Eighty-eight T2-weighted images in 18 patients demonstrated abnormal PSMA expression within the TZ on PET-MR. 123 images were PSMA negative. Based on the corrected p-value of 0.005, significant differences between PSMA positive and negative slices were found for 16 texture parameters: Standard deviation and mean of positive pixels for all spatial filters (p = <0.0001 for both at all spatial scaling factor (SSF) values) and mean intensity following filtration for SSF 3–6 mm (p = 0.0002–0.0018). CONCLUSION: Abnormal expression of PSMA within the TZ is associated with altered texture on T2-weighted MR, providing validation of MRTA for the detection of TZ prostate cancer.

Type: Article
Title: Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00330-017-4877-x
Publisher version: https://doi.org/10.1007/s00330-017-4877-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Magnetic resonance imaging, Texture analysis, Prostate, Cancer, Diagnosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10055286
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