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C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

Ezcurra, M; Benedetto, A; Sornda, T; Gilliat, AF; Au, C; Zhang, Q; van Schelt, S; ... Gems, D; + view all (2018) C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies. Current Biology , 28 (16) 2544-2556.e5. 10.1016/j.cub.2018.06.035. Green open access

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Abstract

Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In C. elegans, a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagy-mediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies and can also extend lifespan. This defines a disease syndrome leading to multimorbidity and contributing to late-life mortality. Activation of gut-to-yolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis).

Type: Article
Title: C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2018.06.035
Publisher version: https://doi.org/10.1016/j.cub.2018.06.035
Language: English
Additional information: © 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: aging, atrophy, autophagy, C. elegans, intestine, insulin/IGF-1 signaling, pathology, steatosis, vitellogenin, yolk
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10055183
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