Ankcorn, M;
Moreira, F;
Ijaz, S;
Symes, A;
Buckland, MS;
Workman, S;
Warburton, F;
... Lowe, DM; + view all
(2019)
Absence of Persistent Hepatitis E Virus Infection in Antibody-Deficient Patients Is Associated With Transfer of Antigen-Neutralizing Antibodies From Immunoglobulin Products.
The Journal of Infectious Diseases
, 219
(2)
pp. 245-253.
10.1093/infdis/jiy504.
Preview |
Text
Lowe_Absence of persistent Hepatitis E virus infection in antibody-deficient patients_AAM2.pdf - Accepted Version Download (640kB) | Preview |
Abstract
BACKGROUND: Persistent hepatitis E virus (HEV) infection is described in a number of immunosuppressive conditions. We aimed to determine the risk of persistent HEV infection in patients with primary or secondary antibody deficiency. METHODS: Two hundred and forty five antibody deficient patients on regular immunoglobulin replacement were tested for HEV RNA and anti-HEV IgG. Immunoglobulin products and plasma from nine antibody-deficient patients pre- and post-IVIG, five recently treated patients with persistent HEV infection and five healthy patients recovered from acute HEV infection were analysed for anti-HEV IgG and for antibody reacting with HEV antigen (HEV-Ag). RESULTS: No antibody deficient patient had detectable plasma HEV RNA. Anti-HEV IgG was detected in 38.8% of patients. All ten immunoglobulin products tested contained anti-HEV capable of neutralising HEV-Ag. Plasma samples following IVIG infusion demonstrated higher anti-HEV IgG and neutralising activity compared with pre-IVIG samples. Neutralising activity was similar to healthy patients with recent acute HEV infection. CONCLUSION: The risk of persistent HEV infection in patients with antibody deficiency appears extremely low. This may be due to passive seroprotection afforded by the ubiquitous presence of anti-HEV in immunoglobulin replacement products.
Archive Staff Only
 |
View Item |
