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Towards the integration of the anaerobic ethyl (S)-3-hydroxybutyrate production process into a biorefinery concept

Hirschmann, R; Borodkin, N; Baganz, F; Hass, VC; (2018) Towards the integration of the anaerobic ethyl (S)-3-hydroxybutyrate production process into a biorefinery concept. Chemical Engineering Transactions , 70 pp. 559-564. 10.3303/CET1870094. Green open access

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Abstract

Ethyl (S)-3-hydroxybutyrate ((S)-E3HB) is naturally found as part of kiwi fruit aroma and is an important precursor for the production of several pharmaceuticals. (S)-E3HB can be produced in a whole cell biotransformation process from Ethylacetoacetate (EAA) using the yeast Saccharomyces cerevisiae. One way of improving the sustainability of such processes may be their integration into novel biorefinery concepts, which requires research to characterize the process and the byproduct formation. In this study it could be shown that (S)-E3HB biocatalysis with S. cerevisiae can be performed under anaerobic conditions with production rates between 4.0 × 10-3and 2.5 × 10-2g(S)-E3HB gbiomass-1h-1which are similar to the rates in conventional aerobic processes. The byproduct spectrum allows for the integration of the new anaerobic biotransformation process into a recently invented biorefinery concept in which the side product CO2is further utilized to produce methane.

Type: Article
Title: Towards the integration of the anaerobic ethyl (S)-3-hydroxybutyrate production process into a biorefinery concept
Open access status: An open access version is available from UCL Discovery
DOI: 10.3303/CET1870094
Publisher version: http://www.aidic.it/cet/18/70/094.pdf
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10055038
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