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Intracranial Volume and Head Circumference in Children with Unoperated Syndromic Craniosynostosis

Breakey, RWF; Knoops, PGM; Borghi, A; Rodriguez-Florez, N; O'Hara, J; James, G; Dunaway, DJ; ... Jeelani, NUO; + view all (2018) Intracranial Volume and Head Circumference in Children with Unoperated Syndromic Craniosynostosis. Plastic and Reconstructive Surgery , 142 (5) 708e-717e. 10.1097/PRS.0000000000004843. Green open access

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Abstract

OBJECTIVE: When analysing intracranial volume gain due to operative intervention in craniosynostosis, it is necessary to understand the underlying growth. We sought to create comprehensive intracranial volume (ICV) and occipitofrontal circumference (OFC) growth charts, as measured on unoperated craniosynostotic children. Furthermore, we aimed to investigate whether ICV and OFC could act as a proxy measure for each other. METHODS: All pre-operative Great Ormond Street Hospital (GOSH) patients with a diagnosis of Apert, Crouzon-Pfeiffer or Saethre-Chotzen syndrome from 2004 onwards were considered for this study. A control group of unaffected GOSH patients were also measured. ICV and OFC were measured on the same scans. To study correlation between IVC and OFC, logarithmic fits were assessed. RESULTS: 147 craniosynostotic children with 221 preoperative scans were included (81 Apert, 81 Crouzon, 31 Pfeiffer, and 28 Saethre-Chotzen). The control group comprised 56 patients with 58 scans. Apert ICV curves were significantly larger than other syndromes from 206 days onwards, OFC curves were not significantly different. The correlation coefficient between ICV and OFC for all syndromes combined was R2 = 0.87, for the control group R2 = 0.91. CONCLUSIONS: Apert children have a larger intracranial volume than other syndromic craniosynostotic conditions and unaffected children but maintain a similar occipitofrontal circumference. This study demonstrates high correlation between intracranial volume and OFC with clinical care implications. Reference growth curves have been created which can be used to monitor intracranial volume change over time and correct operative change for underlying growth.

Type: Article
Title: Intracranial Volume and Head Circumference in Children with Unoperated Syndromic Craniosynostosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/PRS.0000000000004843
Publisher version: http://dx.doi.org/10.1097/PRS.0000000000004843
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Childrens Cardiovascular Disease
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10054968
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