Aggio, D;
Papachristou, E;
Papacosta, O;
Lennon, LT;
Ash, S;
Whincup, PH;
Wannamethee, SG;
(2018)
Association Between Twenty-Year Trajectories of Non-Occupational Physical Activity From Midlife to Old Age and Biomarkers of Cardiovascular Disease: A 20-Year Longitudinal Study of British Men.
American Journal of Epidemiology
, 187
(11)
pp. 2315-2323.
10.1093/aje/kwy157.
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Abstract
The trajectories of physical activity (PA) from midlife into old age and their associations with established and novel cardiovascular disease (CVD) risk factors in later life remain unclear. This study examined associations between 20-year non-occupational PA trajectories and a range of CVD biomarkers at 60-79 years. 3,331 men (mean baseline age = 50.2 ± 5.8 years) recruited in 1978-80 were followed up after 12, 16 and 20 years, reporting habitual non-occupational PA at each wave. At the 20-year follow up, surviving men attended a physical examination and provided a fasting blood sample. Group-based trajectory modelling was used to identify trajectories. Adjusted regression analyses examined the association between trajectory group membership and several cardiometabolic, cardiac and inflammatory markers at follow up. Three distinct 20-year trajectories were identified: low decreasing (21.3%), light stable (51.8%) and moderate increasing (27.0%). Compared to the low decreasing group, membership of the light stable and moderate increasing trajectory groups was associated with a more favorable cardiometabolic profile, lower levels of inflammation and endothelial dysfunction. Although following a moderate increasing PA trajectory was most favorable, more modest but sustained doses of PA into old age may be sufficient to lower CVD risk.
| Type: | Article |
|---|---|
| Title: | Association Between Twenty-Year Trajectories of Non-Occupational Physical Activity From Midlife to Old Age and Biomarkers of Cardiovascular Disease: A 20-Year Longitudinal Study of British Men. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/aje/kwy157 |
| Publisher version: | https://doi.org/10.1093/aje/kwy157 |
| Language: | English |
| Additional information: | © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Ageing, cardiovascular biomarkers, cardiovascular disease, inflammation, physical activity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Psychology and Human Development UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10054919 |
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