Konijnenberg, E;
Carter, SF;
ten Kate, M;
den Braber, A;
Tomassen, J;
Amadi, C;
Wesselman, L;
... Visser, PJ; + view all
(2018)
The EMIF-AD PreclinAD study: study design and baseline cohort overview.
Alzheimer's Research & Therapy
, 10
, Article 75. 10.1186/s13195-018-0406-7.
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Abstract
BACKGROUND: Amyloid pathology is the pathological hallmark in Alzheimer’s disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid pathology leads to cognitive impairment and dementia. To design AD prevention trials it is key to include cognitively normal subjects at high risk for amyloid pathology and to find predictors of cognitive decline in these subjects. These goals can be accomplished by targeting twins, with additional benefits to identify genetic and environmental pathways for amyloid pathology, other AD biomarkers, and cognitive decline. METHODS: From December 2014 to October 2017 we enrolled cognitively normal participants aged 60 years and older from the ongoing Manchester and Newcastle Age and Cognitive Performance Research Cohort and the Netherlands Twins Register. In Manchester we included single individuals, and in Amsterdam monozygotic twin pairs. At baseline, participants completed neuropsychological tests and questionnaires, and underwent physical examination, blood sampling, ultrasound of the carotid arteries, structural and resting state functional brain magnetic resonance imaging, and dynamic amyloid positron emission tomography (PET) scanning with [18F]flutemetamol. In addition, the twin cohort underwent lumbar puncture for cerebrospinal fluid collection, buccal cell collection, magnetoencephalography, optical coherence tomography, and retinal imaging. RESULTS: We included 285 participants, who were on average 74.8 ± 9.7 years old, 64% female. Fifty-eight participants (22%) had an abnormal amyloid PET scan. CONCLUSIONS: A rich baseline dataset of cognitively normal elderly individuals has been established to estimate risk factors and biomarkers for amyloid pathology and future cognitive decline
| Type: | Article |
|---|---|
| Title: | The EMIF-AD PreclinAD study: study design and baseline cohort overview |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13195-018-0406-7 |
| Publisher version: | http://dx.doi.org/10.1186/s13195-018-0406-7 |
| Language: | English |
| Additional information: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Preclinical Alzheimer's disease, Amyloid, Cognitively normal, Monozygotic twins, [F-18]flutemetamol, NETHERLANDS TWIN REGISTER, CEREBROSPINAL-FLUID BIOMARKERS, BETA-AMYLOID BURDEN, ALZHEIMERS-DISEASE, OLDER-ADULTS, ENVIRONMENTAL-INFLUENCES, CAROTID ATHEROSCLEROSIS, DIAGNOSTIC-CRITERIA, COGNITIVE DECLINE, BRAIN ATROPHY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10054808 |
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