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Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury

Ong, S-B; Katwadi, K; Kwek, X-Y; Ismail, NI; Chinda, K; Ong, S-G; Hausenloy, DJ; (2018) Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury. Expert Opinion on Therapeutic Targets , 22 (3) pp. 247-261. 10.1080/14728222.2018.1439015. Green open access

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Abstract

INTRODUCTION: New treatments are required to improve clinical outcomes in patients with acute myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart failure. Following AMI, acute ischemia/reperfusion injury (IRI) ensues, resulting in cardiomyocyte death and impaired cardiac function. Emerging studies have implicated a fundamental role for non-coding RNAs (microRNAs [miRNA], and more recently long non-coding RNAs [lncRNA]) in the setting of acute myocardial IRI. AREAS COVERED: In this article, we discuss the roles of miRNAs and lncRNAs as potential biomarkers and therapeutic targets for the detection and treatment of AMI, review their roles as mediators and effectors of cardioprotection, particularly in the settings of interventions such as ischemic pre- and post-conditioning (IPC & IPost) as well as remote ischemic conditioning (RIC), and highlight future strategies for targeting ncRNAs to reduce MI size and prevent heart failure following AMI. EXPERT OPINION: Investigating the roles of miRNAs and lncRNAs in the setting of AMI has provided new insights into the pathophysiology underlying acute myocardial IRI, and has identified novel biomarkers and therapeutic targets for detecting and treating AMI. Pharmacological and genetic manipulation of these ncRNAs has the therapeutic potential to improve clinical outcomes in AMI patients.

Type: Article
Title: Non-coding RNAs as therapeutic targets for preventing myocardial ischemia-reperfusion injury
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/14728222.2018.1439015
Publisher version: http://dx.doi.org/10.1080/14728222.2018.1439015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Ischemia-reperfusion injury, long non-coding RNA, microRNAs, non-coding RNAs, acute myocardial infarction, cardioprotection, ischemic conditioning, INDUCED CARDIOMYOCYTE APOPTOSIS, PERMEABILITY TRANSITION PORE, HYPOXIA-INDUCED APOPTOSIS, CARDIAC ISCHEMIA/REPERFUSION INJURY, PRESERVES MITOCHONDRIAL-FUNCTION, REGULATES PROGRAMMED NECROSIS, DOWN-REGULATION, PROTECTS CARDIOMYOCYTES, CIRCULATING MICRORNAS, HEART-FAILURE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10054733
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