Rizzo, FM;
Meyer, T;
(2018)
Liquid Biopsies for Neuroendocrine Tumors: Circulating Tumor Cells, DNA, and MicroRNAs.
Endocrinology and Metabolism Clinics of North America
, 47
(3)
pp. 471-483.
10.1016/j.ecl.2018.04.002.
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Abstract
KEY POINTS: 1.: Although there have been significant improvements in neuroendocrine tumors treatment over the last years, novel biomarkers are needed to help clinicians in the management of neuroendocrine tumors. 2.: Liquid biopsies are faster, more economical, and less invasive than tissue biopsies, and have the potential to monitor therapeutic response and to predict recurrences through serial sampling. 3.: Circulating tumor cells, circulating tumor DNA, and microRNAs have recently emerged as prognostic and predictive novel biomarkers in neuroendocrine tumors. 4.: Larger, prospective studies are required to fully understand the role of these biomarkers in neuroendocrine tumorigenesis and to incorporate them into routine clinical practice.
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