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Monoclonal gammopathy of undetermined significance and smoldering myeloma (SMM): a practical guide to management

Maciocia, N; Wechalekar, A; Yong, K; (2016) Monoclonal gammopathy of undetermined significance and smoldering myeloma (SMM): a practical guide to management. Hematological Oncology , 35 (4) pp. 432-439. 10.1002/hon.2345. Green open access

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Abstract

Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are precursor conditions of symptomatic multiple myeloma (MM). Diagnostic principles are aimed at excluding MM requiring therapy, other conditions associated with paraproteins that may require different management, and risk stratifying patients for the purposes of tailored follow‐up and investigation. The International Myeloma Working Group have recently published a revised definition of MM, which singles out a small group of patients with smoldering multiple myeloma who are at very high risk of progression and organ damage; such patients are now included under the definition of MM and recommended to start anti‐myeloma treatment. Furthermore, the recently published National Institute of Health and Care Excellence guideline recommends cross‐sectional imaging techniques in place of skeletal survey. These recent recommendations are discussed, and practical guidance for investigation and management are presented.

Type: Article
Title: Monoclonal gammopathy of undetermined significance and smoldering myeloma (SMM): a practical guide to management
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hon.2345
Publisher version: https://doi.org/10.1002/hon.2345
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Hematology, gammopathy, myeloma, paraprotein, plasma cells, smoldering, ASYMPTOMATIC MULTIPLE-MYELOMA, MULTIPARAMETER FLOW-CYTOMETRY, INDEPENDENT RISK-FACTOR, MARROW PLASMA-CELLS, LIGHT-CHAIN RATIO, SIGNIFICANCE MGUS, MALIGNANT-TRANSFORMATION, GENETIC EVENTS, PROGRESSION, DIAGNOSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10054534
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