Parkkinen, V-P;
Wallmann, C;
Wilde, M;
Clarke, B;
Illari, P;
Kelly, MP;
Norell, C;
+ view all
(2018)
Evaluating Evidence of Mechanisms in Medicine: Principles and Procedures.
[Book].
Springer: Cham, Switzerland.
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Abstract
This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.
| Type: | Book |
|---|---|
| Title: | Evaluating Evidence of Mechanisms in Medicine: Principles and Procedures |
| ISBN: | 3319946099 |
| ISBN-13: | 9783319946092 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-94610-8 |
| Publisher version: | https://doi.org/10.1007/978-3-319-94610-8 |
| Language: | English |
| Additional information: | Copyright © The Editor(s) (if applicable) and The Author(s) 2018. This book is an open access publication. Open Access This book is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. |
| Keywords: | Evidence-based medicine, Mechanisms in medicine, Evaluating evidence, Medical methodology, Evidence hierarchy, Philosophy of medicine, Mechanisms in literature, Mechanism hypothesis, Hypothesize a mechanism, evidence of mechanisms, Assessing exposures, evidence and status of claim, Humanities Research, Evidence-Based Medicine (EBM), Molecular epidemiology, ebmplus.org, analogous epistemic theory, external validity, effects of environmental exposures, Open access |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Science and Technology Studies |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10054036 |
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