Piña-Fuentes, D;
Beudel, M;
Little, SJ;
van Zijl, J;
Elting, JW;
Oterdoom, DLM;
van Egmond, ME;
... Tijssen, MAJ; + view all
(2018)
Toward adaptive deep brain stimulation for dystonia.
Journal of Neurosurgery
, 45
(2)
, Article E3. 10.3171/2018.5.FOCUS18155.
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Abstract
The presence of abnormal neural oscillations within the cortico-basal ganglia-thalamo-cortical (CBGTC) network has emerged as one of the current principal theories to explain the pathophysiology of movement disorders. In theory, these oscillations can be used as biomarkers and thereby serve as a feedback signal to control the delivery of deep brain stimulation (DBS). This new form of DBS, dependent on different characteristics of pathological oscillations, is called adaptive DBS (aDBS), and it has already been applied in patients with Parkinson’s disease. In this review, the authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with dystonia.
| Type: | Article |
|---|---|
| Title: | Toward adaptive deep brain stimulation for dystonia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3171/2018.5.FOCUS18155 |
| Publisher version: | http://doi.org/10.3171/2018.5.FOCUS18155 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | adaptive deep brain stimulation, dystonia, local field potentials, electromyography, low-frequency oscillations |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053866 |
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