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CMOS Image Sensor for Lateral Flow Immunoassay Readers

Pilavaki, E; Valente, V; Demosthenous, A; (2018) CMOS Image Sensor for Lateral Flow Immunoassay Readers. IEEE Transactions on Circuits and Systems II: Express Briefs , 65 (10) pp. 1405-1409. 10.1109/TCSII.2018.2855054. Green open access

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Abstract

Point-of-care systems for the detection of infectious diseases are in great demand especially in developing countries. Lateral flow immunoassays are considered ideal biosensors for point-of-care diagnostics due to their numerous advantages. However, to quantify their results a low power, robust electronic reader is needed. A low power CMOS image sensor is presented that can be used in quantitative lateral flow immunoassay readers. It uses a single low power processing capacitive transimpedance amplifier architecture which includes noise cancellation. A chip containing 4 × 64 pixels was fabricated in CMOS 0.35-μm technology. With uniform illumination at 525 nm and 67 frames per second the chip has 1.9 mVrms total output referred noise and a total power consumption of 21 μW. In tests with lateral flow immunoassays the chip detected concentrations of influenza A nucleoprotein from 0.5 ng/mL to 200 ng/mL.

Type: Article
Title: CMOS Image Sensor for Lateral Flow Immunoassay Readers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TCSII.2018.2855054
Publisher version: https://doi.org/10.1109/TCSII.2018.2855054
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10053760
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