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In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model

Yaghini, E; Turner, H; Pilling, A; Naasani, I; MacRobert, A; (2018) In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model. Nanomedicine: Nanotechnology, Biology and Medicine , 14 pp. 2644-2655. 10.1016/j.nano.2018.07.009. Green open access

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Abstract

Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for biomedical applications owing to their excellent photophysical properties. However, toxicity concerns about commonly used cadmium-based QDs hinder their translation to clinical applications. In this study we describe the in vivo biodistribution and toxicology of indium-based water soluble QDs in rats following intravenous administration. The biodistribution measured at up to 90days showed that QDs mainly accumulated in the liver and spleen, with similar elimination kinetics to subcutaneous administration. Evidence for QD degradation in the liver was found by comparing photoluminescence measurements versus elemental analysis. No organ damage or histopathological lesions were observed for the QDs treated rats after 24hr., 1 and 4weeks following intravenous administration at 12.5mg/kg or 50mg/kg. Analysis of serum biochemistry and complete blood counts found no toxicity. This work supports the strong potential of indium-based QDs for translation into the clinic.

Type: Article
Title: In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nano.2018.07.009
Publisher version: https://doi.org/10.1016/j.nano.2018.07.009
Language: English
Additional information: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.
Keywords: Biodistribution, Cadmium-free quantum dots, Nanoparticles, Toxicology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10053707
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