Tembo, J;
Chandwe, K;
Kabwe, M;
Chilufya, M;
Ciccone, O;
Mpabalwani, E;
Ablashi, D;
... Bates, M; + view all
(2018)
Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case‐control study in a referral hospital in Zambia.
Journal of Medical Virology
, 90
(11)
pp. 1757-1764.
10.1002/jmv.25269.
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Abstract
BACKGROUND: Human herpesvirus 6B (HHV-6B) is the causative agent of Roseola infantum, and has also been suggested to play a role in the pathogenesis of febrile seizures in young children, a percentage of whom go on to develop febrile status epilepticus (FSE), but existing data is conflicting and inconclusive. HHV-6A is a distinct species, rarely detected in most parts of the world, but prior studies suggest a higher prevalence in febrile African children. We describe a case control study comparing the frequency of HHV-6A and/or HHV-6B infections in children with febrile seizures (including febrile status epilepticus) and a control group of febrile children without seizures. METHODS: We recruited children aged 6-60 months admitted with a febrile illness with (cases) or without (controls) seizures presenting within 48 hours of commencement of fever. 3mls of whole blood was centrifuged and plasma stored at -80o C for pooled screening for HHV-6B and HHV-6A by Taqman Real Time PCR. RESULTS: 102 cases and 95 controls were recruited. The prevalence of HHV-6B DNA detection did not differ significantly between cases (5.8% (6/102)) and controls (10.5% (10/95)) but HHV-6B infection was associated with febrile status epilepticus (OR 15; 95% CI, [1.99-120]; p=0.009). HHV-6A was not detected. CONCLUSION: Prevalence of HHV-6B was similar among cases and controls. Within the febrile seizure group, HHV-6B infection was associated with FSE, suggesting HHV-6B infections could play a role in pathogenesis of FSE.
| Type: | Article |
|---|---|
| Title: | Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case‐control study in a referral hospital in Zambia |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jmv.25269 |
| Publisher version: | https://doi.org/10.1002/jmv.25269 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | HHV-6A, HHV-6B, Human Herpesvirus 6, case-control, febrile seizures, febrile status epilepticus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053559 |
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