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A reversible fluorescent probe for monitoring Ag(I) ions

Lim, Z; Smith, DG; Kolanowski, JL; Mattison, RL; Knowles, JC; Baek, S-Y; Chrzanowski, W; (2018) A reversible fluorescent probe for monitoring Ag(I) ions. Journal of the Royal Society Interface , 15 (144) 10.1098/rsif.2018.0346. Green open access

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Abstract

Silver-containing nanomaterials are of interest for their antibiotic properties, for a wide range of applications from medicine to consumer products. However, much remains to be learnt about the degradation of such materials and their effects on human health. While most analyses involve measurement of total silver levels, it is important also to be able to measure concentrations of active free Ag(I) ions. We report here the preparation of a coumarin-based probe, thiocoumarin silver sensor 1 (TcAg1), that responds reversibly to the addition of silver ions through the appearance of a new fluorescence emission peak at 565 nm. Importantly, this peak is not observed in the presence of Hg(II), a common interferent in Ag(I) sensing. To establish the utility of this sensor, we prepared silver-doped phosphate glasses with demonstrated bactericidal properties, and observed the Ag(I) release from these glasses in solutions of different ionic strength. TcAg1 is therefore a useful tool for the study of the environmental and medical effects of silver-containing materials.

Type: Article
Title: A reversible fluorescent probe for monitoring Ag(I) ions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsif.2018.0346
Publisher version: https://doi.org/10.1098/rsif.2018.0346
Language: English
Additional information: Copyright © 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, provided the original author and source are credited.
Keywords: silver, fluorescent probe, phosphate glass, antibacterial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10053535
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