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Neuroscience of apathy and anhedonia: a transdiagnostic approach

Husain, M; Roiser, JP; (2018) Neuroscience of apathy and anhedonia: a transdiagnostic approach. Nature Reviews Neuroscience , 19 (8) pp. 470-484. 10.1038/s41583-018-0029-9. Green open access

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Abstract

Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions.

Type: Article
Title: Neuroscience of apathy and anhedonia: a transdiagnostic approach
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41583-018-0029-9
Publisher version: http://doi.org/10.1038/s41583-018-0029-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10053434
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