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A Perspective of AMD Through the Eyes of Immunology

Copland, DA; Theodoropoulou, S; Liu, J; Dick, AD; (2018) A Perspective of AMD Through the Eyes of Immunology. Investigative Ophthalmology & Visual Science , 59 (4) AMD83-AMD92. 10.1167/iovs.18-23893. Green open access

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Abstract

Despite strong genetic associations, compelling human histological data and numerous hypotheses generated with supportive animal data, the mechanisms of inflammation or inflammatory control of cell health during progression of age-related macular degeneration arguably remain elusive. This perspective delivers a view that maintaining tissue health requires active immune cellular and tissue pathways, but when responses are perturbed or exaggerated, chronic inflammation is destructive. There are potential pathways and processes to enable understanding and determine how potential causative factors including altered cellular metabolism, senescence, oxidative stress disrupt tissue homeostasis are engaged. Establishing differences in the immune phenotype between normal aging and AMD, and how the inter-relatedness of these triggers contribute to pathobiology is integral for future therapeutic success.

Type: Article
Title: A Perspective of AMD Through the Eyes of Immunology
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.18-23893
Publisher version: https://doi.org/10.1167/iovs.18-23893
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For further information see: https://creativecommons.org/licenses/by-nc-nd/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10053343
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