UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tremor in motor neuron disease may be central rather than peripheral in origin

Latorre, A; Rocchi, L; Stamelou, M; Batla, A; Ciocca, M; Balint, B; Sidle, K; ... Bhatia, KP; + view all (2019) Tremor in motor neuron disease may be central rather than peripheral in origin. European Journal of Neurology , 26 (3) 394-e31. 10.1111/ene.13743. Green open access

[thumbnail of Latorre_et_al-2018-European_Journal_of_Neurology.pdf]
Preview
Text
Latorre_et_al-2018-European_Journal_of_Neurology.pdf - Accepted Version

Download (769kB) | Preview

Abstract

BACKGROUND: Motor neuron disease (MND) refers to a spectrum of degenerative diseases affecting motor neurons. Recent clinical and postmortem observations have revealed considerable variability in the phenotype. Rhythmic involuntary oscillations of the hands during action, resembling tremor, can occur in MND, but its pathophysiology has not yet been investigated. METHODS: 120 consecutive MND patients were screened for tremor. Twelve patients with action tremor and no other movement disorders were found. Ten took part in the study. Tremor was recorded bilaterally using surface electromyography and triaxial accelerometer, with and without a variable weight load. Power spectra of rectified electromyography and accelerometric signal were calculated. To investigate a possible cerebellar involvement, eye blink classic conditioning (EBCC) was performed in five patients. RESULTS: Action tremor was present in about 10% of our population. All patients showed distal postural tremor of low amplitude and constant frequency, bilateral with a small degree of asymmetry. Two of them showed also simple kinetic tremor. A peak at the electromyography and accelerometric recordings ranging from 4 Hz to 12 Hz was found in all patients. Loading did not change peak frequency in either the electromyographic or accelerometric power spectra. Compared with healthy volunteers, patients had a smaller number of conditioned responses during EBCC. CONCLUSIONS: our data suggest that MND patients can present with action tremor of a central origin, possibly due to a cerebellar dysfunction. This evidence supports the novel idea of MND as a multisystem neurodegenerative disease and that action tremor can be part of this condition.

Type: Article
Title: Tremor in motor neuron disease may be central rather than peripheral in origin
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ene.13743
Publisher version: https://doi.org/10.1111/ene.13743
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Motor neuron disease, cerebellum, eye blink classic conditioning, power spectrum, tremor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10053331
Downloads since deposit
673Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item