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Long-term cardiovascular health in adult cancer survivors

Naaktgeboren, WR; Linschoten, M; de Graeff, A; van Rhenen, A; Cramer, MJ; Asselbergs, FW; Maas, AHEM; (2017) Long-term cardiovascular health in adult cancer survivors. Maturitas , 105 pp. 37-45. 10.1016/j.maturitas.2017.05.014. Green open access

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Abstract

The number of cancer survivors has tremendously increased over the past decades as a result of aging of the population and improvements in early cancer detection and treatment. Ongoing successes in cancer treatment are expected to result in a further increase in the number of long-term survivors. However, cancer treatment can have detrimental cardiovascular side-effects that impact morbidity and mortality, reducing quality of life in cancer survivors. The spectrum of radiotherapy- and chemotherapy-induced cardiovascular disease is broad, varying from subclinical valvular dysfunction to overt congestive heart failure, and such effects may not be apparent for more than twenty years after the initial cancer treatment. Awareness of these long-term side-effects is of crucial value in the management of these patients, in order to reduce the impact of cardiovascular morbidity and mortality. This review provides a comprehensive overview of the long-term cardiovascular complications of cancer treatments (radiotherapy and chemotherapy) in adult cancer survivors.

Type: Article
Title: Long-term cardiovascular health in adult cancer survivors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.maturitas.2017.05.014
Publisher version: https://doi.org/10.1016/j.maturitas.2017.05.014
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Obstetrics & Gynecology, Cardiotoxicity, Cancer Survivor, Radiotherapy, Chemotherapy, Cardiovascular Disease, Cardio-Oncology, Stage Breast-Cancer, Androgen-Deprivation Therapy, Coronary-Artery-Disease, Hodgkins-Disease, Heart-Disease, Valvular Dysfunction, Cardiac Toxicity, Risk-Factors, Follow-Up, Anthracycline Cardiotoxicity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/10053247
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