Kajihara, M;
Montagnese, S;
Khanna, P;
Amodio, P;
Schapira, AHV;
Dusheiko, GM;
Morgan, MY;
(2010)
Parkinsonism in patients with chronic hepatitis C treated with interferon-alpha 2b: a report of two cases.
European Journal of Gastroenterology & Hepatology
, 22
(5)
pp. 628-631.
10.1097/MEG.0b013e32833383e3.
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Abstract
Details of two patients with chronic hepatitis C who developed features of Parkinsonism when treated with IFN-2b and ribavirin are reported. The symptoms resolved when treatment was discontinued in one patient but not in the other. Physicians should be alert to the possibility that drug-related Parkinsonism may complicate treatment of hepatitis C with antiviral agents; the agent most likely responsible is INF-2b. Prompt withdrawal of treatment is mandatory but does not always guarantee reversal of the Parkinsonian features.
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