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Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia

Tangvoraphonkchai, K; Hung, R; Sadeghi-Alavijeh, O; Davenport, A; (2018) Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia. Nutrition in Clinical Practice , 33 (2) pp. 255-260. 10.1002/ncp.10003. Green open access

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Abstract

BACKGROUND: Muscle weakness is associated with increased mortality, and hemodialysis (HD) patients are at an increased risk for muscle loss. There is no agreed definition for muscle weakness, so we determined whether using different cut‐off criteria recommended by guideline groups altered the prevalence in HD patients. METHODS: We measured hand grip strength (HGS) in HD outpatients, comparing HGS with clinical guideline cut‐offs (European Working Group on Sarcopenia in Older People [EWGSOP] and North American Foundation for the National Institutes of Health Sarcopenia Project [FNIH]) used to define muscle wasting (sarcopenia) with age‐matched and gender‐matched normative data. RESULTS: We studied 459 patients, 61.4% male, 47.3% diabetic. The prevalence of muscle weakness was significantly different when measuring HGS; 84.5% using the EWGSOP cut‐off and 73.2% with FNIH criteria, and 75.2% using North American normative data and 56.6% U.K. normative data (P < .01). On logistic regression, muscle weakness was associated with age (odds ratio [OR] 1.05, P < .001), weight (OR 0.96, P < .001), serum albumin (OR 0.89, P = .007), and being nondiabetic (OR 0.31, P = .001). Of patients with no comorbidity, 66.7% were weak when compared with 93.8% with the highest comorbidity scores (P < .001). CONCLUSION: There is currently no agreed universal definition for sarcopenia, but the EWGSOP and FNIH advocate HGS cut‐offs as part of their definition. The prevalence of muscle weakness varies according to cut‐off and whether age‐matched and gender‐matched normative data are used. In addition, patient characteristics in terms of age and comorbidity determine the prevalence of muscle weakness.

Type: Article
Title: Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ncp.10003
Publisher version: https://doi.org/10.1002/ncp.10003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: hand strength, muscle weakness, sarcopenia, nutrition assessment, renal dialysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10053130
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