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Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study

McCutcheon, R; Bloomfield, MAP; Dahoun, T; Quinlan, M; Terbeck, S; Mehta, M; Howes, O; (2018) Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study. Psychological Medicine , 48 (12) pp. 1985-1992. 10.1017/S0033291717003506. Green open access

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Abstract

BACKGROUND: Ethnic minority individuals have an increased risk of developing a psychotic disorder, particularly if they live in areas of ethnic segregation, or low own group ethnic density. The neurobiological mechanisms underlying this ethnic minority associated risk are unknown. We used functional MRI to investigate neural responses to faces of different ethnicity, in individuals of black ethnicity, and a control group of white British ethnicity individuals. METHODS: In total 20 individuals of black ethnicity, and 22 individuals of white British ethnicity underwent a 3T MRI scan while viewing faces of black and white ethnicity. Own group ethnic density was calculated from the 2011 census. Neighbourhood segregation was quantified using the Index of Dissimilarity method. RESULTS: At the within-group level, both groups showed greater right amygdala activation to outgroup faces. Between groups, the black ethnicity group showed greater right amygdala activation to white faces, compared to the white ethnicity group. Within the black ethnicity group, individuals living in areas of lower own group ethnic density showed greater right amygdala reactivity to white faces (r = -0.61, p = 0.01). CONCLUSIONS: This is the first time an increased amygdala response to white faces has been demonstrated in individuals of black ethnicity. In the black ethnicity group, correlations were observed between amygdala response and neighbourhood variables associated with increased psychosis risk. These results may have relevance for our understanding of the increased rates of paranoia and psychotic disorders in ethnic minority individuals.

Type: Article
Title: Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0033291717003506
Publisher version: https://doi.org/10.1017/S0033291717003506
Language: English
Additional information: © Cambridge University Press 2018. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Amygdala, ethnic density, ethnic minority, ethnicity, fMRI, paranoia, psychosis, risk factors, schizophrenia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10053031
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