%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Philipp Berens, Jeremy Freeman, Thomas Deneux, Nikolay Chenkov, Thomas McColgan, Artur Speiser, Jakob H. Macke, Srinivas C. Turaga, Patrick Mineault, Peter Rupprecht, Stephan Gerhard, Rainer W. Friedrich, Johannes Friedrich, Liam Paninski, Marius Pachitariu, Kenneth D. Harris, Ben Bolte, Timothy A. Machado, Dario Ringach, Jasmine Stone, Luke E. Rogerson, Nicolas J. Sofroniew, Jacob Reimer, Emmanouil Froudarakis, Thomas Euler, Miroslav Román Rosón, Lucas Theis, Andreas S. Tolias, Matthias Bethge
Community-based benchmarking improves spike rate inference from two-photon calcium imaging data
www.ploscompbiol.org
www.ploscompbiol.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref005)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref008)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref009)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref004)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref006)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref014)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref016)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref017)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
33 0 obj
<>/Border[0 0 0]/A 34 0 R>>
endobj
34 0 obj
<>
endobj
14 0 obj
[35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
endobj
35 0 obj
<>stream
q
0.955 g
0 w
199.9998 641.23 m
575.9997 641.23 l
575.9997 480.2304 l
199.9998 480.2304 l
f*
0.45 0.36 0.35 0.01 k
575.9997 666.2299 m
199.9998 666.2299 l
199.9998 666.7299 l
575.9997 666.7299 l
f*
0.83 0.64 0.02 0 k
431.263 393.9024 m
436.0252 393.9024 l
h
f*
440.4472 393.9024 m
445.2094 393.9024 l
h
f*
338.2866 367.937 m
343.0488 367.937 l
h
f*
348.2646 367.937 m
352.9701 367.937 l
h
f*
504.737 341.915 m
509.4992 341.915 l
h
f*
514.715 341.915 m
519.4205 341.915 l
h
f*
533.0268 276.9449 m
537.789 276.9449 l
h
f*
542.2677 276.9449 m
551.7921 276.9449 l
h
f*
281.537 263.9055 m
286.2992 263.9055 l
h
f*
290.778 263.9055 m
300.3024 263.9055 l
h
f*
455.9244 263.9055 m
460.6866 263.9055 l
h
f*
465.1654 263.9055 m
474.6331 263.9055 l
h
f*
479.1118 263.9055 m
488.6362 263.9055 l
h
f*
283.1811 211.9181 m
292.7055 211.9181 l
h
f*
297.1843 211.9181 m
306.652 211.9181 l
h
f*
230.1165 94.9039 m
239.6409 94.9039 l
h
f*
244.063 94.9039 m
253.5874 94.9039 l
h
f*
405.0142 81.9213 m
414.5386 81.9213 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(algorithms)Tj
4.78 0 Td
(are)Tj
1.6471 0 Td
(based)Tj
2.9063 0 Td
(on)Tj
1.3188 0 Td
(a)Tj
0.7698 0 Td
(wide)Tj
2.2498 0 Td
(range)Tj
2.7452 0 Td
(of)Tj
1.0443 0 Td
(principles)Tj
4.3803 0 Td
(from)Tj
2.208 0 Td
(deep)Tj
2.4169 0 Td
(neural)Tj
2.954 0 Td
(networks)Tj
4.1833 0 Td
(to)Tj
1.0503 0 Td
(generative)Tj
-34.6541 -1.474 Td
(models,)Tj
3.682 0 Td
(yet)Tj
1.5456 0 Td
(provide)Tj
3.4553 0 Td
(highly)Tj
2.7929 0 Td
(correlated)Tj
4.6129 0 Td
(estimates)Tj
4.4579 0 Td
(of)Tj
1.0443 0 Td
(the)Tj
1.5994 0 Td
(neural)Tj
2.9539 0 Td
(activity.)Tj
3.521 0 Td
(The)Tj
1.9335 0 Td
(competition)Tj
-31.5987 -1.474 Td
(shows)Tj
3.0256 0 Td
(that)Tj
1.8738 0 Td
(benchmark)Tj
5.1143 0 Td
(challenges)Tj
4.9352 0 Td
(can)Tj
1.8142 0 Td
(drive)Tj
2.3572 0 Td
(algorithmic)Tj
4.9949 0 Td
(developments)Tj
6.3795 0 Td
(in)Tj
0.9787 0 Td
(neuroscience)Tj
5.8781 0 Td
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 209.9905 623.2251 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 605.2535 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Two-photon)Tj
5.278 0 Td
(calcium)Tj
3.3619 0 Td
(imaging)Tj
3.4866 0 Td
(is)Tj
0.8504 0 Td
(one)Tj
1.7008 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(major)Tj
2.6078 0 Td
(tools)Tj
2.1374 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3924 0 Td
(the)Tj
1.4684 0 Td
(activity)Tj
3.118 0 Td
(of)Tj
1.0148 0 Td
(large)Tj
2.16 0 Td
(popu-)Tj
-33.0857 -1.3039 Td
(lations)Tj
2.8856 0 Td
(of)Tj
1.0148 0 Td
(neurons)Tj
3.5036 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(brain.)Tj
2.5739 0 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(technique,)Tj
4.3936 0 Td
(a)Tj
0.652 0 Td
(fluorescent)Tj
4.6374 0 Td
(calcium)Tj
3.3619 0 Td
(indicator)Tj
3.8664 0 Td
(changes)Tj
-32.1786 -1.2982 Td
(its)Tj
1.1451 0 Td
(brightness)Tj
4.354 0 Td
(when)Tj
2.4038 0 Td
(a)Tj
0.652 0 Td
(neuron)Tj
3.1464 0 Td
(fires)Tj
1.9332 0 Td
(an)Tj
1.2019 0 Td
(action)Tj
2.6986 0 Td
(potential)Tj
3.7587 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(an)Tj
1.2019 0 Td
(associated)Tj
4.2576 0 Td
(increase)Tj
3.4696 0 Td
(in)Tj
-32.9497 -1.2983 Td
(intracellular)Tj
5.0569 0 Td
(calcium.)Tj
3.5887 0 Td
(However,)Tj
4.0762 0 Td
(while)Tj
2.3697 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(algorithms)Tj
4.5184 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1259 0 Td
(proposed)Tj
3.9515 0 Td
(for)Tj
-32.8306 -1.3039 Td
(estimating)Tj
4.405 0 Td
(spike)Tj
2.2847 0 Td
(rates)Tj
2.1089 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(measured)Tj
4.1102 0 Td
(signal,)Tj
2.7666 0 Td
(the)Tj
1.4684 0 Td
(problem)Tj
3.6113 0 Td
(is)Tj
0.8504 0 Td
(far)Tj
1.3096 0 Td
(from)Tj
2.2053 0 Td
(solved.)Tj
2.9707 0 Td
(We)Tj
1.6044 0 Td
(orga-)Tj
-33.3692 -1.2983 Td
(nized)Tj
2.4037 0 Td
(a)Tj
0.652 0 Td
(public)Tj
2.7099 0 Td
(competition)Tj
5.0966 0 Td
(using)Tj
2.3868 0 Td
(a)Tj
0.6576 0 Td
(data)Tj
1.9106 0 Td
(set)Tj
1.3039 0 Td
(for)Tj
1.389 0 Td
(which)Tj
2.6475 0 Td
(ground)Tj
3.1691 0 Td
(truth)Tj
2.2394 0 Td
(data)Tj
1.9162 0 Td
(was)Tj
1.7008 0 Td
(available.)Tj
3.8891 0 Td
(Par-)Tj
-34.0722 -1.2982 Td
(ticipants)Tj
3.6339 0 Td
(were)Tj
2.126 0 Td
(given)Tj
2.3754 0 Td
(a)Tj
0.6577 0 Td
(training)Tj
3.4185 0 Td
(set)Tj
1.304 0 Td
(to)Tj
1.0261 0 Td
(develop)Tj
3.3165 0 Td
(new)Tj
1.8765 0 Td
(algorithms,)Tj
4.7452 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(performance)Tj
5.3517 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.0438 -1.304 Td
(algorithms)Tj
4.5183 0 Td
(was)Tj
1.6952 0 Td
(evaluated)Tj
3.9854 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.652 0 Td
(hidden)Tj
3.0387 0 Td
(test)Tj
1.5987 0 Td
(set.)Tj
1.5251 0 Td
(Here)Tj
2.2053 0 Td
(we)Tj
1.3209 0 Td
(report)Tj
2.7099 0 Td
(on)Tj
1.27 0 Td
(the)Tj
1.4683 0 Td
(results)Tj
2.8063 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(compe-)Tj
-32.7569 -1.2982 Td
(tition)Tj
2.4094 0 Td
(and)Tj
1.7291 0 Td
(discuss)Tj
3.0501 0 Td
(the)Tj
1.4683 0 Td
(progress)Tj
3.5943 0 Td
(made)Tj
2.4265 0 Td
(towards)Tj
3.4015 0 Td
(better)Tj
2.5455 0 Td
(algorithms)Tj
4.5184 0 Td
(to)Tj
1.0261 0 Td
(infer)Tj
2.1147 0 Td
(spiking)Tj
3.1464 0 Td
(activity)Tj
-31.4303 -1.2983 Td
(from)Tj
2.2053 0 Td
(imaging)Tj
3.4866 0 Td
(data.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 425.0267 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 408.0188 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Two-photon)Tj
5.278 0 Td
(calcium)Tj
3.3619 0 Td
(imaging)Tj
3.4866 0 Td
(has)Tj
1.542 0 Td
(become)Tj
3.3222 0 Td
(a)Tj
0.6576 0 Td
(standard)Tj
3.7191 0 Td
(tool)Tj
1.7801 0 Td
(to)Tj
1.0262 0 Td
(probe)Tj
2.5455 0 Td
(the)Tj
1.4683 0 Td
(function)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(neural)Tj
2.7723 0 Td
(cir-)Tj
-35.6029 -1.3039 Td
(cuits)Tj
2.0976 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3868 0 Td
(computations)Tj
5.7316 0 Td
(in)Tj
1.0375 0 Td
(neuronal)Tj
3.8267 0 Td
(populations)Tj
4.9493 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(2)Tj
0 g
(].)Tj
1.2642 0 Td
(Indeed,)Tj
3.2372 0 Td
(the)Tj
1.4683 0 Td
(latest)Tj
2.279 0 Td
(advances)Tj
3.8268 0 Td
(in)Tj
-36.1188 -1.2982 Td
(scanning)Tj
3.8154 0 Td
(technologies)Tj
5.2157 0 Td
(make)Tj
2.3981 0 Td
(it)Tj
0.7823 0 Td
(now)Tj
1.9616 0 Td
(possible)Tj
3.4072 0 Td
(to)Tj
1.0261 0 Td
(record)Tj
2.846 0 Td
(neural)Tj
2.7723 0 Td
(activity)Tj
3.1181 0 Td
(from)Tj
2.2053 0 Td
(hundreds)Tj
4.0365 0 Td
(or)Tj
1.0942 0 Td
(even)Tj
-34.6788 -1.2983 Td
(thousands)Tj
4.3143 0 Td
(of)Tj
1.0148 0 Td
(cells)Tj
1.9162 0 Td
(simultaneously)Tj
6.2418 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
2.5965 0 Td
(However,)Tj
4.0762 0 Td
(the)Tj
1.4684 0 Td
(resulting)Tj
3.7303 0 Td
(fluorescence)Tj
5.1874 0 Td
(signal)Tj
2.5398 0 Td
(is)Tj
0.8504 0 Td
(only)Tj
1.9786 0 Td
(an)Tj
-35.9147 -1.3039 Td
(indirect)Tj
3.3448 0 Td
(measurement)Tj
5.6693 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(underlying)Tj
4.5977 0 Td
(spiking)Tj
3.1465 0 Td
(activity,)Tj
3.3392 0 Td
(as)Tj
1.0148 0 Td
(it)Tj
0.788 0 Td
(reflects)Tj
3.0557 0 Td
(the)Tj
1.4684 0 Td
(comparatively)Tj
5.8733 0 Td
(slow)Tj
-34.7865 -1.2983 Td
(cellular)Tj
3.135 0 Td
(dynamics)Tj
4.0592 0 Td
(of)Tj
1.0148 0 Td
(cellular)Tj
3.1408 0 Td
(calcium)Tj
3.3619 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(fluorescent)Tj
4.6375 0 Td
(calcium)Tj
3.3618 0 Td
(indicators)Tj
4.2236 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
2.5966 0 Td
(Thus,)Tj
2.4718 0 Td
(to)Tj
-35.2004 -1.2982 Td
(relate)Tj
2.4151 0 Td
(large-scale)Tj
4.3993 0 Td
(population)Tj
4.5921 0 Td
(recordings)Tj
4.4844 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(spiking)Tj
3.1408 0 Td
(activity)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(neural)Tj
2.7723 0 Td
(circuits)Tj
3.1634 0 Td
(we)Tj
1.3266 0 Td
(fundamen-)Tj
-32.9213 -1.2983 Td
(tally)Tj
1.8992 0 Td
(require)Tj
3.1124 0 Td
(techniques)Tj
4.524 0 Td
(to)Tj
1.0262 0 Td
(infer)Tj
2.1203 0 Td
(spike)Tj
2.2847 0 Td
(rates)Tj
2.1089 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(fluorescent)Tj
4.6375 0 Td
(traces.)Tj
-24.1907 -1.3039 Td
(Over)Tj
2.2166 0 Td
(the)Tj
1.474 0 Td
(past)Tj
1.8255 0 Td
(decade,)Tj
3.2088 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(algorithms)Tj
4.5184 0 Td
(for)Tj
1.3833 0 Td
(solving)Tj
3.0727 0 Td
(this)Tj
1.6724 0 Td
(problem)Tj
3.6113 0 Td
(have)Tj
2.0637 0 Td
(been)Tj
2.1203 0 Td
(proposed.)Tj
-33.4486 -1.2983 Td
(Many)Tj
2.5511 0 Td
(of)Tj
1.0148 0 Td
(them)Tj
2.2847 0 Td
(assume)Tj
3.1465 0 Td
(a)Tj
0.6576 0 Td
(forward)Tj
3.4015 0 Td
(generative)Tj
4.3314 0 Td
(model)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(calcium)Tj
3.3619 0 Td
(signal)Tj
2.5398 0 Td
(and)Tj
1.7348 0 Td
(attempt)Tj
3.3052 0 Td
(to)Tj
1.0261 0 Td
(invert)Tj
-34.5824 -1.2983 Td
(it)Tj
0.7823 0 Td
(to)Tj
1.0261 0 Td
(infer)Tj
2.1203 0 Td
(spike)Tj
2.2848 0 Td
(rates.)Tj
2.3357 0 Td
(Examples)Tj
4.0535 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(approach)Tj
3.9515 0 Td
(include)Tj
3.1861 0 Td
(deconvolution)Tj
6.0094 0 Td
(techniques)Tj
4.5241 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(10)Tj
0 g
(],)Tj
-34.2252 -1.3039 Td
(template-matching)Tj
7.8122 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(11)Tj
0 g
(])Tj
1.5081 0 Td
(and)Tj
1.7347 0 Td
(approximate)Tj
5.2725 0 Td
(Bayesian)Tj
3.7247 0 Td
(inference)Tj
3.9344 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(13)Tj
0 g
(].)Tj
1.7348 0 Td
(Such)Tj
2.177 0 Td
(forward)Tj
3.4015 0 Td
(mod-)Tj
-35.223 -1.2982 Td
(els)Tj
1.2472 0 Td
(incorporate)Tj
4.8926 0 Td
(a)Tj
0.6519 0 Td
(priori)Tj
2.5228 0 Td
(assumptions)Tj
5.2214 0 Td
(about)Tj
2.4945 0 Td
(how)Tj
1.9389 0 Td
(the)Tj
1.4683 0 Td
(measured)Tj
4.1102 0 Td
(signal)Tj
2.5399 0 Td
(is)Tj
0.8503 0 Td
(generated,)Tj
4.3597 0 Td
(e.g.)Tj
1.559 0 Td
(about)Tj
-33.8567 -1.2983 Td
(the)Tj
1.4683 0 Td
(shape)Tj
2.4831 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(calcium)Tj
3.3618 0 Td
(fluorescence)Tj
5.1874 0 Td
(signal)Tj
2.5455 0 Td
(induced)Tj
3.4639 0 Td
(by)Tj
1.1792 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(spike)Tj
2.2847 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(statistics)Tj
3.5886 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-35.4498 -1.3039 Td
(noise.)Tj
2.5511 0 Td
(In)Tj
1.1112 0 Td
(contrast,)Tj
3.685 0 Td
(comparatively)Tj
5.8734 0 Td
(few)Tj
1.6157 0 Td
(groups)Tj
2.965 0 Td
(have)Tj
2.0636 0 Td
(attempted)Tj
4.2576 0 Td
(to)Tj
1.0262 0 Td
(solve)Tj
2.211 0 Td
(the)Tj
1.474 0 Td
(problem)Tj
3.6113 0 Td
(through)Tj
-32.4451 -1.2983 Td
(supervised)Tj
4.456 0 Td
(learning)Tj
3.5206 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(15)Tj
0 g
(],)Tj
1.7347 0 Td
(where)Tj
2.6476 0 Td
(a)Tj
0.6576 0 Td
(machine)Tj
3.6624 0 Td
(learning)Tj
3.5262 0 Td
(algorithm)Tj
4.1556 0 Td
(is)Tj
0.8447 0 Td
(trained)Tj
3.0954 0 Td
(to)Tj
1.0205 0 Td
(infer)Tj
2.1203 0 Td
(the)Tj
1.4683 0 Td
(spike)Tj
-34.6504 -1.2982 Td
(rate)Tj
1.7461 0 Td
(from)Tj
2.2053 0 Td
(calcium)Tj
3.3619 0 Td
(signal)Tj
2.5398 0 Td
(using)Tj
2.3924 0 Td
(simultaneously)Tj
6.2419 0 Td
(recorded)Tj
3.7984 0 Td
(spike)Tj
2.2847 0 Td
(and)Tj
1.7291 0 Td
(calcium)Tj
3.3619 0 Td
(data)Tj
1.9105 0 Td
(for)Tj
1.389 0 Td
(training.)Tj
-31.7648 -1.304 Td
(Despite)Tj
3.2484 0 Td
(this)Tj
1.6725 0 Td
(progress,)Tj
3.8267 0 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8504 0 Td
(still)Tj
1.6384 0 Td
(an)Tj
1.2019 0 Td
(open)Tj
2.2166 0 Td
(question)Tj
3.6624 0 Td
(whether)Tj
3.4752 0 Td
(current)Tj
3.1862 0 Td
(algorithms)Tj
4.5127 0 Td
(already)Tj
3.1124 0 Td
(achieve)Tj
-34.5824 -1.2982 Td
(the)Tj
1.4683 0 Td
(best)Tj
1.8085 0 Td
(possible)Tj
3.4129 0 Td
(performance)Tj
5.3461 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(task,)Tj
2.0352 0 Td
(or)Tj
1.0942 0 Td
(whether)Tj
3.4809 0 Td
(the)Tj
1.4684 0 Td
(observed)Tj
3.7927 0 Td
(performance)Tj
5.3518 0 Td
(can)Tj
1.6214 0 Td
(still)Tj
1.6384 0 Td
(be)Tj
-35.3761 -1.2983 Td
(improved)Tj
4.1045 0 Td
(upon)Tj
2.3187 0 Td
(by)Tj
1.1792 0 Td
(algorithmic)Tj
4.8416 0 Td
(developments.)Tj
5.998 0 Td
(To)Tj
1.3323 0 Td
(answer)Tj
3.0387 0 Td
(this)Tj
1.6725 0 Td
(question,)Tj
3.8834 0 Td
(we)Tj
1.3266 0 Td
(organized)Tj
4.1726 0 Td
(the)Tj
/F11 1 Tf
1.4683 0 Td
[()10()11()4()8()]TJ
-35.3364 -1.2983 Td
[()-8()12()6( )4()2(\n)]TJ
/F6 1 Tf
2.5284 0 Td
(challenge.)Tj
4.1839 0 Td
(This)Tj
1.99 0 Td
(challenge)Tj
3.9571 0 Td
(aimed)Tj
2.6929 0 Td
(at)Tj
0.9524 0 Td
(two)Tj
1.7065 0 Td
(goals:)Tj
2.4604 0 Td
(\(1\))Tj
1.3777 0 Td
(provide)Tj
3.2881 0 Td
(a)Tj
0.652 0 Td
(standardized)Tj
5.3518 0 Td
(framework)Tj
4.6204 0 Td
(to)Tj
-35.7616 -1.3039 Td
(evaluate)Tj
3.4582 0 Td
(existing)Tj
3.3165 0 Td
(spike)Tj
2.2847 0 Td
(inference)Tj
3.9402 0 Td
(algorithms)Tj
4.5183 0 Td
(on)Tj
1.2756 0 Td
(identical)Tj
3.6567 0 Td
(data)Tj
1.9105 0 Td
(and)Tj
1.7348 0 Td
(\(2\))Tj
1.372 0 Td
(catalyze)Tj
3.3505 0 Td
(the)Tj
1.4684 0 Td
(development)Tj
-32.2864 -1.2982 Td
(of)Tj
1.0147 0 Td
(new)Tj
1.8766 0 Td
(spike)Tj
2.2847 0 Td
(inference)Tj
3.9344 0 Td
(algorithms)Tj
4.5184 0 Td
(through)Tj
3.4469 0 Td
(crowd-sourcing.)Tj
6.7805 0 Td
(Such)Tj
2.177 0 Td
(challenges)Tj
4.3143 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(used)Tj
-34.5314 -1.2983 Td
(successfully)Tj
4.8642 0 Td
(in)Tj
1.0318 0 Td
(machine)Tj
3.668 0 Td
(learning,)Tj
3.7474 0 Td
(computer)Tj
4.1102 0 Td
(vision)Tj
2.6248 0 Td
(or)Tj
1.0999 0 Td
(physics)Tj
3.1294 0 Td
(to)Tj
1.0261 0 Td
(drive)Tj
2.2621 0 Td
(algorithmic)Tj
4.8472 0 Td
(develop-)Tj
-32.4111 -1.3039 Td
(ments)Tj
2.6702 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(17)Tj
0 g
(].)Tj
1.7404 0 Td
(We)Tj
1.6044 0 Td
(present)Tj
3.1635 0 Td
(ten)Tj
1.491 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(submitted)Tj
4.2463 0 Td
(algorithms)Tj
4.5184 0 Td
(which)Tj
2.6532 0 Td
(show)Tj
2.296 0 Td
(improved)Tj
4.1102 0 Td
(perfor-)Tj
-32.7172 -1.2983 Td
(mance)Tj
2.8686 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0261 0 Td
(previously)Tj
4.354 0 Td
(evaluated)Tj
3.9855 0 Td
(methods)Tj
3.685 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0806 0 Td
(Interestingly,)Tj
5.4879 0 Td
(the)Tj
1.474 0 Td
(top-performing)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 347.0173 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Benchmar)Tj
4.4858 0 Td
(king)Tj
2.0197 0 Td
(spike)Tj
2.5087 0 Td
(rate)Tj
1.9134 0 Td
(inference)Tj
4.2591 0 Td
(for)Tj
1.3677 0 Td
(two-photo)Tj
4.3158 0 Td
(n)Tj
0.7654 0 Td
(calcium)Tj
3.5504 0 Td
(imaging)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006157)Tj
0 g
6.3497 0 Td
(May)Tj
2.0835 0 Td
(21,)Tj
1.5874 0 Td
(2018)Tj
27.9923 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(13)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(\\_158428)Tj
3.7559 0 Td
(to)Tj
0.9496 0 Td
(JoF\),)Tj
2.0693 0 Td
(the)Tj
1.3677 0 Td
(European)Tj
3.7418 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(Council)Tj
-15.5765 -1.3748 Td
(\(ERC\))Tj
2.4236 0 Td
(under)Tj
2.3669 0 Td
(the)Tj
1.3678 0 Td
(European)Tj
3.7417 0 Td
(Union's)Tj
3.0331 0 Td
(Horizon)Tj
3.0898 0 Td
(2020)Tj
-16.0229 -1.3749 Td
(research)Tj
3.4157 0 Td
(and)Tj
1.5874 0 Td
(innovation)Tj
4.0749 0 Td
(programm)Tj
3.9614 0 Td
(e)Tj
0.6378 0 Td
(\(grant)Tj
-13.6772 -1.3748 Td
(agreement)Tj
4.1669 0 Td
(No)Tj
1.2827 0 Td
(742576)Tj
3.0614 0 Td
(to)Tj
0.9497 0 Td
(RF\),)Tj
1.7574 0 Td
(the)Tj
1.3749 0 Td
(Boehringe)Tj
3.7559 0 Td
(r)Tj
-16.3489 -1.3748 Td
(Ingelheim)Tj
3.8764 0 Td
(Fonds)Tj
2.4874 0 Td
(\(fellowsh)Tj
3.3732 0 Td
(ip)Tj
0.8859 0 Td
(to)Tj
0.9496 0 Td
(PR\),)Tj
1.8638 0 Td
(the)Tj
1.3748 0 Td
(Novartis)Tj
-14.8111 -1.3748 Td
(Research)Tj
3.6992 0 Td
(Foundation,)Tj
4.5709 0 Td
(the)Tj
1.3748 0 Td
(Simons)Tj
3.0544 0 Td
(Foundation)Tj
-12.6993 -1.3748 Td
(Global)Tj
2.5653 0 Td
(Brain)Tj
2.1402 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(Awards)Tj
3.0118 0 Td
(325171)Tj
2.8347 0 Td
(,)Tj
0.4464 0 Td
(325398,)Tj
-14.6906 -1.3748 Td
(and)Tj
1.5874 0 Td
(365002)Tj
3.0614 0 Td
(\(LP\),)Tj
2.0551 0 Td
(the)Tj
1.3749 0 Td
(Army)Tj
2.2252 0 Td
(Research)Tj
3.6992 0 Td
(Office)Tj
2.3528 0 Td
(MURI)Tj
-16.356 -1.3748 Td
(\(W911NF-)Tj
3.848 0 Td
(12-1-0594,)Tj
4.3725 0 Td
(LP\),)Tj
1.7504 0 Td
(the)Tj
1.3748 0 Td
(Nationa)Tj
2.8205 0 Td
(l)Tj
0.4181 0 Td
(Institutes)Tj
3.6426 0 Td
(of)Tj
-18.2269 -1.3748 Td
(Health)Tj
2.5724 0 Td
(BRAIN)Tj
2.7 0 Td
(Initiative)Tj
3.3024 0 Td
(\(R01EB229)Tj
4.2591 0 Td
(13,)Tj
-12.8339 -1.3749 Td
(R21EY02759)Tj
4.8968 0 Td
(2)Tj
0.6945 0 Td
(to)Tj
0.9496 0 Td
(LP\),)Tj
1.7505 0 Td
(the)Tj
1.3748 0 Td
(Defense)Tj
3.2173 0 Td
(Advanced)Tj
-12.8835 -1.3748 Td
(Research)Tj
3.6992 0 Td
(Projects)Tj
3.2386 0 Td
(Agency)Tj
2.9551 0 Td
(\(DARPA)Tj
3.0544 0 Td
(,)Tj
0.4465 0 Td
(N66001-15-)Tj
4.5142 0 Td
(C-)Tj
-17.908 -1.3748 Td
(4032,)Tj
2.3386 0 Td
(SIMPLEX)Tj
3.7488 0 Td
(to)Tj
0.9496 0 Td
(LP\))Tj
1.5307 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
1.3678 0 Td
(National)Tj
3.2386 0 Td
(Institutes)Tj
-14.7615 -1.3748 Td
(of)Tj
0.9496 0 Td
(Health)Tj
2.5724 0 Td
(\(NEI,)Tj
2.0693 0 Td
(DP1EY0)Tj
3.0544 0 Td
(23176)Tj
2.5866 0 Td
(to)Tj
0.9496 0 Td
(AST\).)Tj
2.2749 0 Td
(In)Tj
0.9496 0 Td
(addition,)Tj
-15.4064 -1.3748 Td
(this)Tj
1.5661 0 Td
(work)Tj
2.0622 0 Td
(was)Tj
1.7008 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
0.6945 0 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3748 0 Td
(Intelligenc)Tj
3.7702 0 Td
(e)Tj
-15.5765 -1.3748 Td
(Advanced)Tj
3.848 0 Td
(Research)Tj
3.6993 0 Td
(Projects)Tj
3.2386 0 Td
(Activity)Tj
2.9055 0 Td
(\(IARPA\))Tj
3.2528 0 Td
(via)Tj
-16.9442 -1.3748 Td
(Department)Tj
4.5921 0 Td
(of)Tj
0.9496 0 Td
(Interior/)Tj
3.1607 0 Td
(Interior)Tj
2.9055 0 Td
(Business)Tj
3.5717 0 Td
(Center)Tj
-15.1796 -1.3749 Td
(\(DoI/IBC\))Tj
3.7134 0 Td
(contract)Tj
3.2457 0 Td
(numbers)Tj
3.5433 0 Td
(D16PC0000)Tj
4.4788 0 Td
(3)Tj
0.6945 0 Td
(and)Tj
-15.6757 -1.3819 Td
(D16PC00)Tj
3.5291 0 Td
(007)Tj
1.6441 0 Td
(\(LP,)Tj
1.7504 0 Td
(JR,)Tj
1.4528 0 Td
(AST,)Tj
1.9701 0 Td
(MB\).)Tj
2.0268 0 Td
(The)Tj
1.5874 0 Td
(funders)Tj
3.0473 0 Td
(had)Tj
-17.008 -1.3748 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
1.7859 0 Td
(collection)Tj
3.7417 0 Td
(and)Tj
-14.3646 -1.3748 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3748 Td
(manuscript.)Tj
4.6417 0 Td
(The)Tj
1.5874 0 Td
(U.S.)Tj
1.7788 0 Td
(Governmen)Tj
4.3299 0 Td
(t)Tj
0.4819 0 Td
(is)Tj
0.8292 0 Td
(authorized)Tj
4.0748 0 Td
(to)Tj
-17.7237 -1.3748 Td
(reproduce)Tj
3.9897 0 Td
(and)Tj
1.5945 0 Td
(distrib)Tj
2.3103 0 Td
(ute)Tj
1.3748 0 Td
(reprints)Tj
3.0685 0 Td
(for)Tj
1.2615 0 Td
(Governme)Tj
3.8551 0 Td
(ntal)Tj
-17.4544 -1.3748 Td
(purposes)Tj
3.685 0 Td
(notwithstandi)Tj
5.0032 0 Td
(ng)Tj
1.1622 0 Td
(any)Tj
1.5378 0 Td
(copyright)Tj
-11.3882 -1.3748 Td
(annotatio)Tj
3.437 0 Td
(n)Tj
0.6945 0 Td
(thereon.)Tj
3.274 0 Td
(The)Tj
1.5874 0 Td
(views)Tj
2.3174 0 Td
(and)Tj
1.5874 0 Td
(conclusions)Tj
-12.8977 -1.3749 Td
(contained)Tj
3.8268 0 Td
(herein)Tj
2.5086 0 Td
(are)Tj
1.3748 0 Td
(those)Tj
2.2607 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(authors)Tj
3.0473 0 Td
(and)Tj
-15.3355 -1.3748 Td
(should)Tj
2.7283 0 Td
(not)Tj
1.4244 0 Td
(be)Tj
1.1126 0 Td
(interpreted)Tj
4.2237 0 Td
(as)Tj
1.063 0 Td
(necessaril)Tj
3.6922 0 Td
(y)Tj
-14.2442 -1.3748 Td
(representin)Tj
4.1669 0 Td
(g)Tj
0.6945 0 Td
(the)Tj
1.3748 0 Td
(official)Tj
2.6221 0 Td
(policies)Tj
3.0118 0 Td
(or)Tj
0.9992 0 Td
(endorsemen)Tj
4.6418 0 Td
(ts,)Tj
-17.5111 -1.3748 Td
(either)Tj
2.2889 0 Td
(expressed)Tj
4.004 0 Td
(or)Tj
0.9992 0 Td
(implied,)Tj
3.1465 0 Td
(of)Tj
0.9496 0 Td
(IARPA,)Tj
2.863 0 Td
(DoI/IBC,)Tj
3.3237 0 Td
(or)Tj
-17.5749 -1.3748 Td
(the)Tj
1.3677 0 Td
(U.S.)Tj
1.7858 0 Td
(Governme)Tj
3.8552 0 Td
(nt.)Tj
1.1764 0 Td
(We)Tj
1.4456 0 Td
(acknowledge)Tj
5.0528 0 Td
(support)Tj
3.0969 0 Td
(by)Tj
-17.7804 -1.3748 Td
(the)Tj
1.3677 0 Td
(Open)Tj
2.1756 0 Td
(Access)Tj
2.8559 0 Td
(Publishin)Tj
3.4158 0 Td
(g)Tj
0.6945 0 Td
(Fund)Tj
2.0622 0 Td
(of)Tj
0.9496 0 Td
(University)Tj
3.9189 0 Td
(of)Tj
-17.4402 -1.3748 Td
(Tu)Tj
0 Tc
0.5598 0 Td
()Tj
-0.025 Tc
0.3898 0 Td
(bingen.)Tj
2.948 0 Td
(Awards)Tj
3.0119 0 Td
(for)Tj
1.2543 0 Td
(the)Tj
1.3677 0 Td
(spikefinder)Tj
4.2804 0 Td
(compe)Tj
2.537 0 Td
(tition)Tj
-16.3489 -1.3749 Td
(were)Tj
2.0126 0 Td
(kindly)Tj
2.3953 0 Td
(provided)Tj
3.4512 0 Td
(by)Tj
1.1197 0 Td
(Carl)Tj
1.6653 0 Td
(Zeiss)Tj
2.1544 0 Td
(AG,)Tj
-12.7985 -1.3748 Td
(Oberkochen)Tj
4.4716 0 Td
(,)Tj
0.4465 0 Td
(Germany)Tj
3.6071 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
1.3678 0 Td
(Bernstein)Tj
3.7134 0 Td
(Center)Tj
2.6291 0 Td
(for)Tj
-17.8229 -1.3748 Td
(Computat)Tj
3.6283 0 Td
(ional)Tj
1.9772 0 Td
(Neuroscienc)Tj
4.6134 0 Td
(e,)Tj
0.8717 0 Td
(Tu)Tj
0 Tc
0.5527 0 Td
()Tj
-0.025 Tc
0.3898 0 Td
(bingen,)Tj
2.9552 0 Td
(Germany.)Tj
/F8 1 Tf
-14.9883 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(I)Tj
0.4748 0 Td
(have)Tj
1.956 0 Td
(read)Tj
1.8425 0 Td
(the)Tj
1.3677 0 Td
(journal's)Tj
-13.8331 -1.3748 Td
(policy)Tj
2.3952 0 Td
(and)Tj
1.5875 0 Td
(the)Tj
1.3748 0 Td
(authors)Tj
3.0402 0 Td
(of)Tj
0.9496 0 Td
(this)Tj
1.5661 0 Td
(manuscript)Tj
4.415 0 Td
(have)Tj
1.9559 0 Td
(the)Tj
-17.2843 -1.3748 Td
(following)Tj
3.5858 0 Td
(competing)Tj
4.1599 0 Td
(interests:)Tj
3.6142 0 Td
(Lucas)Tj
2.4307 0 Td
(Theis)Tj
2.204 0 Td
(is)Tj
0.8362 0 Td
(a)Tj
-16.8308 -1.3748 Td
(paid)Tj
1.7787 0 Td
(employee)Tj
3.8055 0 Td
(of)Tj
ET
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
BT
6.5268 31.0892 Td
(Twitter.)Tj
ET
Q
endstream
endobj
53 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 55 0 R/Contents 56 0 R/TrimBox[0 0 612 792]>>
endobj
55 0 obj
[57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R]
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t001)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref003)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref018)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rsec009)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
64 0 obj
<>/Border[0 0 0]/A 70 0 R>>
endobj
70 0 obj
<>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t002)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t002)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Lpcbi.1006157.t001)>>
endobj
68 0 obj
<>/Border[0 0 0]/A 71 0 R>>
endobj
71 0 obj
<>
endobj
69 0 obj
<>/Border[0 0 0]/A 72 0 R>>
endobj
72 0 obj
<>
endobj
56 0 obj
[73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R]
endobj
73 0 obj
<>stream
q
0.83 0.64 0.02 0 k
217.7008 613.5307 m
246.8409 613.5307 l
h
f*
484.8945 574.526 m
489.6567 574.526 l
h
f*
527.2441 535.5213 m
536.7118 535.5213 l
h
f*
233.5748 431.5465 m
243.0992 431.5465 l
h
f*
480.4157 392.5417 m
515.7921 392.5417 l
h
f*
524.5228 340.5543 m
534.0472 340.5543 l
h
f*
397.1339 301.5496 m
406.6583 301.5496 l
h
f*
209.537 249.5622 m
409.8898 249.5622 l
h
f*
429.7323 249.5622 m
458.8724 249.5622 l
h
f*
339.3071 223.5402 m
368.5039 223.5402 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(algorithms)Tj
4.5183 0 Td
(are)Tj
1.4457 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6576 0 Td
(range)Tj
2.4605 0 Td
(of)Tj
1.0148 0 Td
(principles)Tj
4.1612 0 Td
(from)Tj
2.2053 0 Td
(deep)Tj
2.1147 0 Td
(neural)Tj
2.7722 0 Td
(networks)Tj
3.9118 0 Td
(to)Tj
1.0205 0 Td
(generative)Tj
4.3313 0 Td
(models,)Tj
-34.3613 -1.3039 Td
(yet)Tj
1.3946 0 Td
(provide)Tj
3.2882 0 Td
(highly)Tj
2.7099 0 Td
(correlated)Tj
4.2462 0 Td
(estimates)Tj
3.9061 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(neural)Tj
2.7722 0 Td
(activity.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 657.6377 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 640.6299 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(For)Tj
1.627 0 Td
(the)Tj
/F11 1 Tf
1.4684 0 Td
[()10()11()4()8()1()-8()12()6( )4()2(\n)]TJ
/F6 1 Tf
4.4617 0 Td
(challenge,)Tj
4.1839 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.0579 0 Td
(five)Tj
1.6554 0 Td
(benchmark)Tj
4.7736 0 Td
(data)Tj
1.9105 0 Td
(sets)Tj
1.6668 0 Td
(consisting)Tj
4.2632 0 Td
(in)Tj
1.0375 0 Td
(total)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(92)Tj
-33.4486 -1.3039 Td
(recordings)Tj
4.4843 0 Td
(from)Tj
2.2054 0 Td
(73)Tj
1.1735 0 Td
(neurons,)Tj
3.7304 0 Td
(acquired)Tj
3.702 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4583 0 Td
(visual)Tj
2.5058 0 Td
(cortex)Tj
2.7099 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(retina)Tj
2.5625 0 Td
(of)Tj
1.0148 0 Td
(mice)Tj
-33.2558 -1.2982 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Table)Tj
2.4377 0 Td
(1)Tj
0 g
(\).)Tj
1.2643 0 Td
(In)Tj
1.1055 0 Td
(brief,)Tj
2.3017 0 Td
(data)Tj
1.9162 0 Td
(sets)Tj
1.6611 0 Td
(I,)Tj
0.788 0 Td
(II)Tj
0.9014 0 Td
(and)Tj
1.7292 0 Td
(IV)Tj
1.2529 0 Td
(were)Tj
2.1259 0 Td
(collected)Tj
3.7361 0 Td
(with)Tj
2.0012 0 Td
(OGB-1)Tj
3.0841 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(calcium)Tj
3.3619 0 Td
(dye,)Tj
1.8482 0 Td
(while)Tj
-34.9566 -1.2983 Td
(data)Tj
1.9105 0 Td
(sets)Tj
1.6668 0 Td
(III)Tj
1.2415 0 Td
(and)Tj
1.7291 0 Td
(V)Tj
0.9128 0 Td
(were)Tj
2.126 0 Td
(collected)Tj
3.736 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(genetically)Tj
4.4504 0 Td
(encoded)Tj
3.5999 0 Td
(indicator)Tj
3.8665 0 Td
(GCamp6s.)Tj
4.4276 0 Td
(Similarly,)Tj
-33.1367 -1.3039 Td
(there)Tj
2.262 0 Td
(were)Tj
2.126 0 Td
(differences)Tj
4.5637 0 Td
(in)Tj
1.0375 0 Td
(scanning)Tj
3.8154 0 Td
(method)Tj
3.3222 0 Td
(and)Tj
1.7291 0 Td
(scan)Tj
1.9899 0 Td
(rate)Tj
1.7461 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(data)Tj
1.9106 0 Td
(sets:)Tj
1.8878 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
-33.0177 -1.2983 Td
(data)Tj
1.9105 0 Td
(set)Tj
1.3039 0 Td
(I)Tj
0.5613 0 Td
(was)Tj
1.7008 0 Td
(recorded)Tj
3.7927 0 Td
(using)Tj
2.3924 0 Td
(3D)Tj
1.4287 0 Td
(AOD)Tj
2.3867 0 Td
(scanners)Tj
3.6907 0 Td
(at)Tj
0.9524 0 Td
(very)Tj
1.9276 0 Td
(high)Tj
2.0069 0 Td
(scan)Tj
1.9842 0 Td
(rates)Tj
2.109 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(],)Tj
1.6044 0 Td
(while)Tj
2.3698 0 Td
(data)Tj
1.9105 0 Td
(set)Tj
1.3039 0 Td
(II)Tj
-35.3364 -1.2982 Td
(was)Tj
1.6951 0 Td
(recorded)Tj
3.7984 0 Td
(using)Tj
2.3867 0 Td
(conventional)Tj
5.4312 0 Td
(galvo-scanners)Tj
6.1454 0 Td
(at)Tj
0.9525 0 Td
(fairly)Tj
2.2847 0 Td
(low)Tj
1.6554 0 Td
(speed.)Tj
2.6986 0 Td
(For)Tj
1.627 0 Td
(all)Tj
1.1452 0 Td
(data)Tj
1.9162 0 Td
(sets,)Tj
1.8879 0 Td
(calcium)Tj
-33.6243 -1.2983 Td
(imaging)Tj
3.4865 0 Td
(had)Tj
1.7065 0 Td
(been)Tj
2.126 0 Td
(performed)Tj
4.4673 0 Td
(simultaneously)Tj
6.2419 0 Td
(with)Tj
2.0012 0 Td
(electrophysiological)Tj
8.1354 0 Td
(recordings)Tj
4.4844 0 Td
(allowing)Tj
3.617 0 Td
(to)Tj
-36.2662 -1.3039 Td
(evaluate)Tj
3.4582 0 Td
(the)Tj
1.474 0 Td
(performance)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(spike)Tj
2.2847 0 Td
(rate)Tj
1.7461 0 Td
(inference)Tj
3.9402 0 Td
(algorithms)Tj
4.5184 0 Td
(on)Tj
1.2756 0 Td
(ground)Tj
3.1634 0 Td
(truth)Tj
2.245 0 Td
(data)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.075 0 Td
(Impor-)Tj
-34.4577 -1.2983 Td
(tantly,)Tj
2.7269 0 Td
(all)Tj
1.1452 0 Td
(data)Tj
1.9105 0 Td
(was)Tj
1.7008 0 Td
(acquired)Tj
3.702 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(zoom)Tj
2.4661 0 Td
(factor)Tj
2.5455 0 Td
(typically)Tj
3.5603 0 Td
(used)Tj
2.0579 0 Td
(during)Tj
2.9311 0 Td
(population)Tj
4.592 0 Td
(imaging)Tj
3.4866 0 Td
(experi-)Tj
-34.4293 -1.2983 Td
(ments,)Tj
2.8969 0 Td
(ensuring)Tj
3.7304 0 Td
(that)Tj
1.7802 0 Td
(all)Tj
1.1451 0 Td
(benchmark)Tj
4.7736 0 Td
(results)Tj
2.8062 0 Td
(reflect)Tj
2.6986 0 Td
(performance)Tj
5.3461 0 Td
(under)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(typical)Tj
2.863 0 Td
(use-case)Tj
-32.1276 -1.3039 Td
(conditions.)Tj
1.1962 -1.2982 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(challenge,)Tj
4.1839 0 Td
(we)Tj
1.3323 0 Td
(split)Tj
1.9105 0 Td
(the)Tj
1.4683 0 Td
(data)Tj
1.9106 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(training)Tj
3.4242 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(test)Tj
1.6044 0 Td
(set,)Tj
1.525 0 Td
(making)Tj
3.2541 0 Td
(sure)Tj
1.8993 0 Td
(that)Tj
1.7801 0 Td
(all)Tj
1.1452 0 Td
(record-)Tj
-34.6051 -1.2983 Td
(ings)Tj
1.8595 0 Td
(from)Tj
2.2053 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(neuron)Tj
3.1465 0 Td
(were)Tj
2.1259 0 Td
(either)Tj
2.5285 0 Td
(assigned)Tj
3.6113 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(training)Tj
3.4186 0 Td
(or)Tj
1.0998 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.5988 0 Td
(set.)Tj
1.5307 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4683 0 Td
(training)Tj
-33.3692 -1.3039 Td
(data,)Tj
2.1316 0 Td
(we)Tj
1.3266 0 Td
(made)Tj
2.4151 0 Td
(both)Tj
2.0579 0 Td
(the)Tj
1.4627 0 Td
(calcium)Tj
3.3562 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4627 0 Td
(spike)Tj
2.279 0 Td
(traces)Tj
2.5285 0 Td
(publicly)Tj
3.4016 0 Td
(available,)Tj
3.8891 0 Td
(but)Tj
1.5477 0 Td
(kept)Tj
1.9502 0 Td
(the)Tj
1.4627 0 Td
(spike)Tj
2.2847 0 Td
(traces)Tj
-35.2854 -1.2983 Td
(secret)Tj
2.5171 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.6044 0 Td
(data.)Tj
2.1373 0 Td
(Additionally,)Tj
5.4538 0 Td
(the)Tj
1.4684 0 Td
(publicly)Tj
3.4129 0 Td
(available)Tj
3.6623 0 Td
(data)Tj
1.9162 0 Td
(sets)Tj
1.6668 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(GENIE)Tj
-33.1594 -1.2982 Td
(project)Tj
3.016 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
1.8538 0 Td
(were)Tj
2.1203 0 Td
(available)Tj
3.6681 0 Td
(as)Tj
1.0147 0 Td
(training)Tj
3.4186 0 Td
(data.)Tj
2.1373 0 Td
(This)Tj
1.9899 0 Td
(allowed)Tj
3.2882 0 Td
(participants)Tj
4.9549 0 Td
(to)Tj
1.0262 0 Td
(adjust)Tj
2.6248 0 Td
(their)Tj
2.109 0 Td
(models)Tj
3.1067 0 Td
(on)Tj
-36.3285 -1.304 Td
(the)Tj
1.4683 0 Td
(training)Tj
3.4185 0 Td
(data)Tj
1.9163 0 Td
(set,)Tj
1.525 0 Td
(while)Tj
2.3697 0 Td
(avoiding)Tj
3.6907 0 Td
(overfitting)Tj
4.4107 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(specific)Tj
3.1918 0 Td
(benchmark)Tj
4.7735 0 Td
(data)Tj
1.9105 0 Td
(set)Tj
1.3039 0 Td
(providing)Tj
4.1443 0 Td
(a)Tj
-36.6177 -1.2982 Td
(realistic)Tj
3.3108 0 Td
(estimate)Tj
3.5433 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(generalization)Tj
5.8677 0 Td
(performance.)Tj
5.5728 0 Td
(Participants)Tj
4.9947 0 Td
(could)Tj
2.4547 0 Td
(upload)Tj
2.9821 0 Td
(predictions)Tj
4.7281 0 Td
(for)Tj
-35.943 -1.2983 Td
(the)Tj
1.4683 0 Td
(spike)Tj
2.2847 0 Td
(rate)Tj
1.7461 0 Td
(generated)Tj
4.1386 0 Td
(by)Tj
1.1792 0 Td
(their)Tj
2.109 0 Td
(algorithm)Tj
4.1555 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6576 0 Td
(dedicated)Tj
4.0706 0 Td
(website)Tj
3.1861 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Methods)Tj
0 g
(\))Tj
4.0932 0 Td
(and)Tj
1.7348 0 Td
(see)Tj
1.423 0 Td
(their)Tj
-35.2911 -1.2983 Td
(performance)Tj
5.3461 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(training)Tj
3.4242 0 Td
(set)Tj
1.2983 0 Td
(during)Tj
2.931 0 Td
(the)Tj
1.4683 0 Td
(competition)Tj
5.0967 0 Td
(phase.)Tj
2.7099 0 Td
(Results)Tj
3.0614 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.5987 0 Td
(set)Tj
1.304 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
-35.8467 -1.3039 Td
(accessible)Tj
4.0875 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(participants)Tj
4.9606 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(competition.)Tj
5.3235 0 Td
(The)Tj
1.7858 0 Td
(primary)Tj
3.4526 0 Td
(evaluation)Tj
4.3596 0 Td
(measure)Tj
3.583 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
-35.8296 -1.2982 Td
(competition)Tj
5.0966 0 Td
(was)Tj
1.7008 0 Td
(the)Tj
1.4683 0 Td
(Pearson)Tj
3.4243 0 Td
(correlation)Tj
4.6147 0 Td
(coefficient)Tj
4.3824 0 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(true)Tj
1.8425 0 Td
(spike)Tj
2.2847 0 Td
(trace)Tj
2.1713 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(pre-)Tj
-35.1777 -1.2983 Td
(diction)Tj
3.0557 0 Td
(sampled)Tj
3.5489 0 Td
(at)Tj
0.9525 0 Td
(25)Tj
1.1735 0 Td
(Hz)Tj
1.4003 0 Td
(\(equivalent)Tj
4.6885 0 Td
(to)Tj
1.0261 0 Td
(40)Tj
1.1736 0 Td
(ms)Tj
1.4003 0 Td
(time)Tj
2.0296 0 Td
(bins\))Tj
2.245 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
4.3483 0 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
-30.9144 -1.3039 Td
(We)Tj
1.61 0 Td
(obtained)Tj
3.7361 0 Td
(37)Tj
1.1678 0 Td
(submissions,)Tj
5.3348 0 Td
(from)Tj
2.2053 0 Td
(which)Tj
2.6533 0 Td
(we)Tj
1.3266 0 Td
(selected)Tj
3.3448 0 Td
(all)Tj
1.1452 0 Td
(algorithms)Tj
4.5184 0 Td
(performing)Tj
4.8019 0 Td
(better)Tj
2.5398 0 Td
(than)Tj
-35.5802 -1.2983 Td
(the)Tj
1.4626 0 Td
(spike-triggered-mixtur)Tj
9.1332 0 Td
(e)Tj
0.6349 0 Td
(model)Tj
2.744 0 Td
(algorithm)Tj
4.1499 0 Td
(\(STM\),)Tj
3.101 0 Td
(which)Tj
2.6476 0 Td
(had)Tj
1.7064 0 Td
(previously)Tj
4.3484 0 Td
(been)Tj
2.1146 0 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0205 0 Td
(out-)Tj
-35.909 -1.2983 Td
(perform)Tj
3.5149 0 Td
(other)Tj
2.3471 0 Td
(published)Tj
4.1272 0 Td
(algorithms)Tj
4.5184 0 Td
(on)Tj
1.2756 0 Td
(this)Tj
1.6724 0 Td
(data)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8211 0 Td
(if)Tj
0.7767 0 Td
(there)Tj
2.262 0 Td
(were)Tj
2.126 0 Td
(multiple)Tj
3.566 0 Td
(sub-)Tj
-35.1097 -1.3039 Td
(missions)Tj
3.7133 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(group,)Tj
2.8346 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.0636 0 Td
(the)Tj
1.4683 0 Td
(one)Tj
1.6951 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(highest)Tj
3.0898 0 Td
(correlation)Tj
4.6204 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.5988 0 Td
(set.)Tj
-34.5541 -1.2982 Td
(This)Tj
1.9842 0 Td
(resulted)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(total)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(ten)Tj
1.491 0 Td
(algorithms)Tj
4.5184 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(studied)Tj
3.1521 0 Td
(in)Tj
1.0375 0 Td
(greater)Tj
3.0047 0 Td
(detail)Tj
2.4207 0 Td
(and)Tj
1.7292 0 Td
(that)Tj
1.7744 0 Td
(are)Tj
1.4514 0 Td
(included)Tj
-33.7774 -1.2983 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(paper.)Tj
2.7099 0 Td
(Notebooks)Tj
4.558 0 Td
(and)Tj
1.7348 0 Td
(code)Tj
2.0977 0 Td
(showing)Tj
3.5829 0 Td
(how)Tj
1.9389 0 Td
(to)Tj
1.0261 0 Td
(run)Tj
1.6668 0 Td
(the)Tj
1.4683 0 Td
(individual)Tj
4.2917 0 Td
(algorithms)Tj
4.5127 0 Td
(are)Tj
1.4513 0 Td
(available)Tj
-33.749 -1.2983 Td
(at)Tj
0.83 0.64 0.02 0 k
0.9524 0 Td
(https://github.com/berenslab/spik)Tj
13.5779 0 Td
(efinder_analysis)Tj
0 g
6.6727 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Table)Tj
2.4378 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(While)Tj
2.6475 0 Td
(seven)Tj
2.4322 0 Td
(of)Tj
1.0147 0 Td
(these)Tj
2.2564 0 Td
(algo-)Tj
-35.0246 -1.3039 Td
(rithms)Tj
2.8629 0 Td
(were)Tj
2.126 0 Td
(designed)Tj
3.7644 0 Td
(specifically)Tj
4.5694 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(purpose)Tj
3.4412 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(challenge,)Tj
4.184 0 Td
(three)Tj
2.262 0 Td
(were)Tj
2.1203 0 Td
(heavily)Tj
3.033 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
-36.1811 -1.2982 Td
(methods)Tj
3.685 0 Td
(published)Tj
4.1215 0 Td
(previously)Tj
4.354 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Table)Tj
2.4378 0 Td
(2)Tj
0 g
0.6973 0 Td
(for)Tj
1.389 0 Td
(overview\).)Tj
-17.2572 -1.2983 Td
(Interestingly,)Tj
5.4935 0 Td
(these)Tj
2.2563 0 Td
(submissions)Tj
5.108 0 Td
(include)Tj
3.1805 0 Td
(algorithms)Tj
4.5184 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(very)Tj
1.9275 0 Td
(different)Tj
3.6567 0 Td
(principles:)Tj
4.388 0 Td
(some)Tj
-35.4725 -1.3039 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(algorithms)Tj
4.5184 0 Td
(built)Tj
2.0636 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(classical)Tj
3.4129 0 Td
(generative)Tj
4.3313 0 Td
(models)Tj
3.1067 0 Td
(of)Tj
1.0148 0 Td
(spike-induced)Tj
5.879 0 Td
(calcium)Tj
3.3619 0 Td
(dynamics)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 170.5022 m
575.9997 170.5022 l
575.9997 170.0022 l
35.9997 170.0022 l
f*
105.9239 170.0022 m
105.9239 157.5023 l
105.4239 157.5023 l
105.4239 170.0022 l
f*
105.4239 157.5023 m
35.9997 157.5023 l
35.9997 158.0023 l
105.4239 158.0023 l
f*
196.6377 170.0022 m
196.6377 157.5023 l
196.1376 157.5023 l
196.1376 170.0022 l
f*
196.1376 157.5023 m
105.9239 157.5023 l
105.9239 158.0023 l
196.1376 158.0023 l
f*
275.9581 170.0022 m
275.9581 157.5023 l
275.4581 157.5023 l
275.4581 170.0022 l
f*
275.4581 157.5023 m
196.6377 157.5023 l
196.6377 158.0023 l
275.4581 158.0023 l
f*
387.4637 170.0022 m
387.4637 157.5023 l
386.9637 157.5023 l
386.9637 170.0022 l
f*
386.9637 157.5023 m
275.9581 157.5023 l
275.9581 158.0023 l
386.9637 158.0023 l
f*
489.5824 170.0022 m
489.5824 157.5023 l
489.0824 157.5023 l
489.0824 170.0022 l
f*
489.0824 157.5023 m
387.4637 157.5023 l
387.4637 158.0023 l
489.0824 158.0023 l
f*
575.9997 157.5023 m
489.5824 157.5023 l
489.5824 158.0023 l
575.9997 158.0023 l
f*
105.9239 157.5023 m
105.9239 145.0023 l
105.4239 145.0023 l
105.4239 157.5023 l
f*
105.4239 145.0023 m
35.9997 145.0023 l
35.9997 145.5024 l
105.4239 145.5024 l
f*
196.6377 157.5023 m
196.6377 145.0023 l
196.1376 145.0023 l
196.1376 157.5023 l
f*
196.1376 145.0023 m
105.9239 145.0023 l
105.9239 145.5024 l
196.1376 145.5024 l
f*
275.9581 157.5023 m
275.9581 145.0023 l
275.4581 145.0023 l
275.4581 157.5023 l
f*
275.4581 145.0023 m
196.6377 145.0023 l
196.6377 145.5024 l
275.4581 145.5024 l
f*
387.4637 157.5023 m
387.4637 145.0023 l
386.9637 145.0023 l
386.9637 157.5023 l
f*
386.9637 145.0023 m
275.9581 145.0023 l
275.9581 145.5024 l
386.9637 145.5024 l
f*
489.5824 157.5023 m
489.5824 145.0023 l
489.0824 145.0023 l
489.0824 157.5023 l
f*
489.0824 145.0023 m
387.4637 145.0023 l
387.4637 145.5024 l
489.0824 145.5024 l
f*
575.9997 145.0023 m
489.5824 145.0023 l
489.5824 145.5024 l
575.9997 145.5024 l
f*
105.9239 145.0023 m
105.9239 132.5024 l
105.4239 132.5024 l
105.4239 145.0023 l
f*
105.4239 132.5024 m
35.9997 132.5024 l
35.9997 133.0024 l
105.4239 133.0024 l
f*
196.6377 145.0023 m
196.6377 132.5024 l
196.1376 132.5024 l
196.1376 145.0023 l
f*
196.1376 132.5024 m
105.9239 132.5024 l
105.9239 133.0024 l
196.1376 133.0024 l
f*
275.9581 145.0023 m
275.9581 132.5024 l
275.4581 132.5024 l
275.4581 145.0023 l
f*
275.4581 132.5024 m
196.6377 132.5024 l
196.6377 133.0024 l
275.4581 133.0024 l
f*
387.4637 145.0023 m
387.4637 132.5024 l
386.9637 132.5024 l
386.9637 145.0023 l
f*
386.9637 132.5024 m
275.9581 132.5024 l
275.9581 133.0024 l
386.9637 133.0024 l
f*
489.5824 145.0023 m
489.5824 132.5024 l
489.0824 132.5024 l
489.0824 145.0023 l
f*
489.0824 132.5024 m
387.4637 132.5024 l
387.4637 133.0024 l
489.0824 133.0024 l
f*
575.9997 132.5024 m
489.5824 132.5024 l
489.5824 133.0024 l
575.9997 133.0024 l
f*
105.9239 132.5024 m
105.9239 120.0025 l
105.4239 120.0025 l
105.4239 132.5024 l
f*
105.4239 120.0025 m
35.9997 120.0025 l
35.9997 120.5025 l
105.4239 120.5025 l
f*
196.6377 132.5024 m
196.6377 120.0025 l
196.1376 120.0025 l
196.1376 132.5024 l
f*
196.1376 120.0025 m
105.9239 120.0025 l
105.9239 120.5025 l
196.1376 120.5025 l
f*
275.9581 132.5024 m
275.9581 120.0025 l
275.4581 120.0025 l
275.4581 132.5024 l
f*
275.4581 120.0025 m
196.6377 120.0025 l
196.6377 120.5025 l
275.4581 120.5025 l
f*
387.4637 132.5024 m
387.4637 120.0025 l
386.9637 120.0025 l
386.9637 132.5024 l
f*
386.9637 120.0025 m
275.9581 120.0025 l
275.9581 120.5025 l
386.9637 120.5025 l
f*
489.5824 132.5024 m
489.5824 120.0025 l
489.0824 120.0025 l
489.0824 132.5024 l
f*
489.0824 120.0025 m
387.4637 120.0025 l
387.4637 120.5025 l
489.0824 120.5025 l
f*
575.9997 120.0025 m
489.5824 120.0025 l
489.5824 120.5025 l
575.9997 120.5025 l
f*
105.9239 120.0025 m
105.9239 107.5025 l
105.4239 107.5025 l
105.4239 120.0025 l
f*
105.4239 107.5025 m
35.9997 107.5025 l
35.9997 108.0026 l
105.4239 108.0026 l
f*
196.6377 120.0025 m
196.6377 107.5025 l
196.1376 107.5025 l
196.1376 120.0025 l
f*
196.1376 107.5025 m
105.9239 107.5025 l
105.9239 108.0026 l
196.1376 108.0026 l
f*
275.9581 120.0025 m
275.9581 107.5025 l
275.4581 107.5025 l
275.4581 120.0025 l
f*
275.4581 107.5025 m
196.6377 107.5025 l
196.6377 108.0026 l
275.4581 108.0026 l
f*
387.4637 120.0025 m
387.4637 107.5025 l
386.9637 107.5025 l
386.9637 120.0025 l
f*
386.9637 107.5025 m
275.9581 107.5025 l
275.9581 108.0026 l
386.9637 108.0026 l
f*
489.5824 120.0025 m
489.5824 107.5025 l
489.0824 107.5025 l
489.0824 120.0025 l
f*
489.0824 107.5025 m
387.4637 107.5025 l
387.4637 108.0026 l
489.0824 108.0026 l
f*
575.9997 107.5025 m
489.5824 107.5025 l
489.5824 108.0026 l
575.9997 108.0026 l
f*
105.9239 107.5025 m
105.9239 95.0026 l
105.4239 95.0026 l
105.4239 107.5025 l
f*
105.4239 95.0026 m
35.9997 95.0026 l
35.9997 95.5026 l
105.4239 95.5026 l
f*
196.6377 107.5025 m
196.6377 95.0026 l
196.1376 95.0026 l
196.1376 107.5025 l
f*
196.1376 95.0026 m
105.9239 95.0026 l
105.9239 95.5026 l
196.1376 95.5026 l
f*
275.9581 107.5025 m
275.9581 95.0026 l
275.4581 95.0026 l
275.4581 107.5025 l
f*
275.4581 95.0026 m
196.6377 95.0026 l
196.6377 95.5026 l
275.4581 95.5026 l
f*
387.4637 107.5025 m
387.4637 95.0026 l
386.9637 95.0026 l
386.9637 107.5025 l
f*
386.9637 95.0026 m
275.9581 95.0026 l
275.9581 95.5026 l
386.9637 95.5026 l
f*
489.5824 107.5025 m
489.5824 95.0026 l
489.0824 95.0026 l
489.0824 107.5025 l
f*
489.0824 95.0026 m
387.4637 95.0026 l
387.4637 95.5026 l
489.0824 95.5026 l
f*
575.9997 95.0026 m
489.5824 95.0026 l
489.5824 95.5026 l
575.9997 95.5026 l
f*
0.83 0.64 0.02 0 k
36 81.9213 m
184.5354 81.9213 l
h
f*
0 g
7.9999 0 0 7.9999 36 175.3511 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
0.9567 0 Td
(Overview)Tj
4.1386 0 Td
(over)Tj
2.0268 0 Td
(datasets)Tj
3.5575 0 Td
(with)Tj
2.0693 0 Td
(trainin)Tj
2.8772 0 Td
(g)Tj
0.7086 0 Td
(and)Tj
1.7788 0 Td
(test)Tj
1.7079 0 Td
(data)Tj
2.0268 0 Td
(used)Tj
2.1189 0 Td
(in)Tj
1.063 0 Td
(the)Tj
1.5378 0 Td
(competi)Tj
3.3661 0 Td
(tion.)Tj
0 Tc
-29.934 -1.8567 Td
(Dataset)Tj
6.4417 0 Td
(Scan)Tj
2.1827 0 Td
(method)Tj
9.156 0 Td
(Indicator)Tj
12.593 0 Td
(Avg.)Tj
2.1402 0 Td
(scan)Tj
2.0693 0 Td
(rate)Tj
1.878 0 Td
(\(Hz\))Tj
7.852 0 Td
(N)Tj
0.9638 0 Td
(in)Tj
1.0842 0 Td
(trainin)Tj
2.9127 0 Td
(g)Tj
0.7228 0 Td
(set)Tj
7.0796 0 Td
(N)Tj
0.9638 0 Td
(in)Tj
1.0842 0 Td
(test)Tj
1.7363 0 Td
(set)Tj
/F6 1 Tf
-59.4288 -1.559 Td
(I)Tj
5.1307 0 Td
(3D)Tj
1.4457 0 Td
(AOD)Tj
9.893 0 Td
(OGB-1)Tj
15.4135 0 Td
(322.5)Tj
13.9395 0 Td
(11)Tj
12.0544 0 Td
(5)Tj
-58.054 -1.5662 Td
(II)Tj
5.3079 0 Td
(galvo)Tj
11.3387 0 Td
(OGB-1)Tj
15.8883 0 Td
(11.8)Tj
13.4647 0 Td
(21)Tj
11.8134 0 Td
(10)Tj
-57.9831 -1.559 Td
(III)Tj
5.478 0 Td
(resonant)Tj
11.3387 0 Td
(GCamp6s)Tj
15.8883 0 Td
(59.1)Tj
13.4647 0 Td
(13)Tj
12.0544 0 Td
(6)Tj
-58.2241 -1.5662 Td
(IV)Tj
5.478 0 Td
(galvo)Tj
11.3387 0 Td
(OGB-1)Tj
16.3631 0 Td
(7.8)Tj
13.2308 0 Td
(6)Tj
11.8135 0 Td
(3)Tj
-58.054 -1.5591 Td
(V)Tj
5.3079 0 Td
(resonant)Tj
11.3387 0 Td
(GCamp6s)Tj
15.8883 0 Td
(59.1)Tj
13.7056 0 Td
(9)Tj
11.8135 0 Td
(8)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.025 Tc
-61.8595 -1.8779 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pc)Tj
3.4583 0 Td
(bi.1006157.)Tj
4.4292 0 Td
(t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 347.0173 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Benchmar)Tj
4.4858 0 Td
(king)Tj
2.0197 0 Td
(spike)Tj
2.5087 0 Td
(rate)Tj
1.9134 0 Td
(inference)Tj
4.2591 0 Td
(for)Tj
1.3677 0 Td
(two-photo)Tj
4.3158 0 Td
(n)Tj
0.7654 0 Td
(calcium)Tj
3.5504 0 Td
(imaging)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006157)Tj
0 g
6.3497 0 Td
(May)Tj
2.0835 0 Td
(21,)Tj
1.5874 0 Td
(2018)Tj
27.9923 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
83 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 84 0 R/Contents 85 0 R/TrimBox[0 0 612 792]>>
endobj
84 0 obj
[86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R]
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref006)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref012)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.s001)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref013)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref019)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.s001)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref020)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref021)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t003)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.g001)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t004)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.t004)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref015)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Lpcbi.1006157.t002)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref012)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref013)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006157.ref028)>>
endobj
104 0 obj
<>/Border[0 0 0]/A 108 0 R>>
endobj
108 0 obj
<>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Lpcbi.1006157.t003)>>
endobj
106 0 obj
<>/Border[0 0 0]/A 109 0 R>>
endobj
109 0 obj
<>
endobj
107 0 obj
<>/Border[0 0 0]/A 110 0 R>>
endobj
110 0 obj
<>
endobj
85 0 obj
[111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R]
endobj
111 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 521.1213 m
208.1764 521.1213 l
h
f*
340.6677 495.0992 m
350.1921 495.0992 l
h
f*
501.789 469.1339 m
531.4961 469.1339 l
h
f*
374.9669 430.1291 m
384.4346 430.1291 l
h
f*
388.9134 430.1291 m
398.4378 430.1291 l
h
f*
498.5575 391.1244 m
508.0252 391.1244 l
h
f*
379.389 326.1543 m
409.0961 326.1543 l
h
f*
245.3102 287.1496 m
254.778 287.1496 l
h
f*
334.2047 287.1496 m
343.7291 287.1496 l
h
f*
276.7181 274.1102 m
305.8583 274.1102 l
h
f*
311.5276 248.1449 m
367.937 248.1449 l
h
f*
372.4157 248.1449 m
401.6126 248.1449 l
h
f*
378.7087 222.1228 m
407.9055 222.1228 l
h
f*
446.0598 222.1228 m
455.5843 222.1228 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 522.1984 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(],)Tj
1.5987 0 Td
(while)Tj
2.3697 0 Td
(others)Tj
2.7099 0 Td
(relied)Tj
2.4775 0 Td
(on)Tj
1.2756 0 Td
(purely)Tj
2.7609 0 Td
(data-driven)Tj
4.8586 0 Td
(training)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(deep)Tj
2.1147 0 Td
(neural)Tj
2.7722 0 Td
(networks)Tj
3.9061 0 Td
(or)Tj
1.0999 0 Td
(pursued)Tj
-32.3771 -1.2982 Td
(hybrid)Tj
2.8743 0 Td
(strategies.)Tj
4.1499 0 Td
(Algorithms)Tj
4.7678 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(generative)Tj
4.3313 0 Td
(models)Tj
3.1011 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(calcium)Tj
3.3618 0 Td
(fluorescence)Tj
5.1874 0 Td
(include)Tj
-34.0098 -1.3039 Td
(the)Tj
1.4683 0 Td
(MLspike)Tj
3.7133 0 Td
(algorithm)Tj
4.1613 0 Td
(by)Tj
1.1792 0 Td
(Team)Tj
2.5115 0 Td
(1)Tj
0.6916 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(],)Tj
2.0806 0 Td
(which)Tj
2.6476 0 Td
(performs)Tj
3.8777 0 Td
(efficient)Tj
3.447 0 Td
(Bayesian)Tj
3.7247 0 Td
(inference)Tj
3.9401 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(bio-)Tj
-35.1323 -1.2983 Td
(physical)Tj
3.4525 0 Td
(model)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(measured)Tj
4.1046 0 Td
(fluorescence)Tj
5.1874 0 Td
(including)Tj
4.0421 0 Td
(a)Tj
0.6577 0 Td
(drifting)Tj
3.2484 0 Td
(baseline)Tj
3.4356 0 Td
(and)Tj
1.7291 0 Td
(nonlinear)Tj
4.1159 0 Td
(calcium)Tj
-33.732 -1.2983 Td
(to)Tj
1.0261 0 Td
(fluorescence)Tj
5.1874 0 Td
(conversion)Tj
4.6317 0 Td
(\(for)Tj
1.7235 0 Td
(a)Tj
0.652 0 Td
(detailed)Tj
3.3732 0 Td
(description)Tj
4.7281 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(algorithm,)Tj
4.3823 0 Td
(see)Tj
0.83 0.64 0.02 0 k
1.4287 0 Td
(S1)Tj
1.1735 0 Td
(Text)Tj
0 g
(\).)Tj
2.5795 0 Td
(Within)Tj
-33.9304 -1.2982 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(group)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(algorithms,)Tj
4.7452 0 Td
(Team)Tj
2.5058 0 Td
(6)Tj
0.6973 0 Td
(took)Tj
2.0296 0 Td
(a)Tj
0.652 0 Td
(decidedly)Tj
4.0421 0 Td
(different)Tj
3.6567 0 Td
(approach,)Tj
4.1783 0 Td
(approximating)Tj
6.1341 0 Td
(the)Tj
-35.9884 -1.3039 Td
(calcium)Tj
3.3618 0 Td
(fluorescence)Tj
5.1874 0 Td
(by)Tj
1.1792 0 Td
(an)Tj
1.2019 0 Td
(autoregressive)Tj
5.913 0 Td
(process)Tj
3.1805 0 Td
(and)Tj
1.7291 0 Td
(finding)Tj
3.1351 0 Td
(the)Tj
1.4683 0 Td
(spike)Tj
2.2847 0 Td
(trains)Tj
2.5002 0 Td
(by)Tj
1.1848 0 Td
(solving)Tj
3.0671 0 Td
(a)Tj
-35.3931 -1.2983 Td
(non-negative)Tj
5.4878 0 Td
(sparse)Tj
2.6872 0 Td
(optimization)Tj
5.3631 0 Td
(problem)Tj
3.617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(19)Tj
0 g
(].)Tj
1.7348 0 Td
(A)Tj
0.9071 0 Td
(similar)Tj
2.982 0 Td
(approach)Tj
3.9572 0 Td
(was)Tj
1.6951 0 Td
(taken)Tj
2.4207 0 Td
(by)Tj
1.1849 0 Td
(Team)Tj
2.5058 0 Td
(7,)Tj
-36.2775 -1.2983 Td
(who)Tj
1.9388 0 Td
(used)Tj
/F11 1 Tf
2.058 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 245.2535 416.5228 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 248.8251 418.2236 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-deconvolution)Tj
6.3552 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(linear)Tj
2.5115 0 Td
(model)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(calcium)Tj
3.3619 0 Td
(fluorescence)Tj
5.1874 0 Td
(with)Tj
1.9955 0 Td
(exponential)Tj
4.9039 0 Td
(cal-)Tj
-34.6447 -1.3039 Td
(cium)Tj
2.2564 0 Td
(filters.)Tj
-1.0602 -1.2982 Td
(In)Tj
1.1055 0 Td
(contrast,)Tj
3.6793 0 Td
(many)Tj
2.4661 0 Td
(other)Tj
2.3414 0 Td
(algorithms)Tj
4.5071 0 Td
(took)Tj
2.0239 0 Td
(a)Tj
0.6463 0 Td
(purely)Tj
2.7553 0 Td
(data-driven)Tj
4.8472 0 Td
(approach)Tj
3.9458 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(])Tj
1.8425 0 Td
(and)Tj
1.7234 0 Td
(trained)Tj
3.0784 0 Td
(dif-)Tj
-36.1584 -1.2983 Td
(ferent)Tj
2.5739 0 Td
(variants)Tj
3.3844 0 Td
(of)Tj
1.0148 0 Td
(deep)Tj
2.1146 0 Td
(neural)Tj
2.7723 0 Td
(networks)Tj
3.9118 0 Td
(to)Tj
1.0205 0 Td
(learn)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(relationship)Tj
4.989 0 Td
(between)Tj
3.5319 0 Td
(measured)Tj
4.1102 0 Td
(spike)Tj
2.2847 0 Td
(and)Tj
-35.4214 -1.3039 Td
(calcium)Tj
3.3619 0 Td
(traces.)Tj
2.7551 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
3.7757 0 Td
(the)Tj
1.4684 0 Td
(algorithm)Tj
4.1555 0 Td
(by)Tj
1.1793 0 Td
(Team)Tj
2.5114 0 Td
(2)Tj
0.6974 0 Td
(used)Tj
2.0579 0 Td
(a)Tj
0.652 0 Td
(straightforward)Tj
6.4289 0 Td
(network)Tj
3.5489 0 Td
(archi-)Tj
-34.2195 -1.2983 Td
(tecture)Tj
2.9877 0 Td
(with)Tj
1.9955 0 Td
(eight)Tj
2.1997 0 Td
(convolutional)Tj
5.7373 0 Td
(layers)Tj
2.5114 0 Td
(with)Tj
1.9956 0 Td
(consecutively)Tj
5.5786 0 Td
(smaller)Tj
3.1237 0 Td
(convolutional)Tj
5.7373 0 Td
(filters)Tj
2.4718 0 Td
(and)Tj
1.7348 0 Td
(one)Tj
-36.0734 -1.2982 Td
(intermediate)Tj
5.3234 0 Td
(recurrent)Tj
3.9798 0 Td
(LSTM)Tj
2.7326 0 Td
(layer.)Tj
2.3754 0 Td
(The)Tj
1.7858 0 Td
(filters)Tj
2.4718 0 Td
(learned)Tj
3.1974 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8028 0 Td
(layer)Tj
2.1543 0 Td
(provide)Tj
3.2882 0 Td
(a)Tj
0.6519 0 Td
(rich)Tj
1.8085 0 Td
(basis)Tj
2.1487 0 Td
(set)Tj
-36.2265 -1.2983 Td
(for)Tj
1.3833 0 Td
(different)Tj
3.6566 0 Td
(spike-calcium)Tj
5.777 0 Td
(relationships)Tj
5.3517 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(S1)Tj
1.1679 0 Td
(Text)Tj
0 g
(\).)Tj
2.5852 0 Td
(Similarly,)Tj
4.0308 0 Td
(the)Tj
1.4684 0 Td
(algorithm)Tj
4.1555 0 Td
(by)Tj
1.1792 0 Td
(Team)Tj
2.5115 0 Td
(5)Tj
0.6917 0 Td
(used)Tj
-35.7276 -1.3039 Td
(fairly)Tj
2.2791 0 Td
(standard)Tj
3.7246 0 Td
(components,)Tj
5.3971 0 Td
(consisting)Tj
4.2689 0 Td
(of)Tj
1.0148 0 Td
(convolutional)Tj
5.7373 0 Td
(and)Tj
1.7291 0 Td
(max-pooling)Tj
5.3462 0 Td
(layers.)Tj
2.7382 0 Td
(In)Tj
1.1055 0 Td
(contrast,)Tj
-33.3408 -1.2983 Td
(the)Tj
1.4684 0 Td
(algorithms)Tj
4.5126 0 Td
(proposed)Tj
3.9515 0 Td
(by)Tj
1.1792 0 Td
(Teams)Tj
2.8629 0 Td
(3,)Tj
0.9185 0 Td
(4,)Tj
0.9184 0 Td
(and)Tj
1.7291 0 Td
(8)Tj
0.6916 0 Td
(combined)Tj
4.2407 0 Td
(more)Tj
2.3414 0 Td
(involved)Tj
3.6453 0 Td
(elements)Tj
3.7644 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0091 0 Td
(resid-)Tj
-35.291 -1.2983 Td
(ual)Tj
1.4287 0 Td
(blocks)Tj
2.7609 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(])Tj
1.8481 0 Td
(or)Tj
1.0998 0 Td
(inception)Tj
4.0195 0 Td
(cells)Tj
1.9219 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7859 0 Td
(key)Tj
1.593 0 Td
(features)Tj
3.3449 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(different)Tj
3.651 0 Td
(DNN-based)Tj
5.0343 0 Td
(approaches)Tj
-33.0517 -1.3039 Td
(are)Tj
1.4457 0 Td
(summarized)Tj
5.1872 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Table)Tj
2.4378 0 Td
(3)Tj
0 g
(.)Tj
-8.912 -1.2982 Td
(The)Tj
1.7858 0 Td
(best)Tj
1.8085 0 Td
(algorithm)Tj
4.1555 0 Td
(increased)Tj
4.0025 0 Td
(the)Tj
1.4683 0 Td
(average)Tj
3.2258 0 Td
(correlation)Tj
4.6205 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(test)Tj
1.5987 0 Td
(set)Tj
1.304 0 Td
(from)Tj
2.2053 0 Td
(0.36)Tj
1.8709 0 Td
(by)Tj
1.1848 0 Td
(0.08)Tj
1.8709 0 Td
(to)Tj
-35.0416 -1.2983 Td
(0.44)Tj
1.8709 0 Td
(compared)Tj
4.2461 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(STM)Tj
2.1997 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1A)Tj
1.3777 0 Td
(and)Tj
1.7291 0 Td
(1B)Tj
0 g
(;)Tj
0.83 0.64 0.02 0 k
1.5023 0 Td
(Table)Tj
2.4435 0 Td
(4)Tj
0 g
(\).)Tj
1.2586 0 Td
(This)Tj
1.9899 0 Td
(corresponds)Tj
5.1363 0 Td
(to)Tj
1.0261 0 Td
(an)Tj
1.2019 0 Td
(increase)Tj
3.4753 0 Td
(of)Tj
1.0148 0 Td
(more)Tj
-34.7865 -1.3039 Td
(than)Tj
2.0296 0 Td
(40%)Tj
1.9276 0 Td
(in)Tj
1.0317 0 Td
(variance)Tj
3.5773 0 Td
(explained)Tj
4.0762 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(best)Tj
1.8085 0 Td
(algorithms,)Tj
4.7395 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(improvement)Tj
5.6693 0 Td
(seen)Tj
-33.1991 -1.2983 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4682 0 Td
(STM)Tj
2.1997 0 Td
(algorithm)Tj
4.1612 0 Td
(and)Tj
1.7292 0 Td
(f-oopsi)Tj
3.016 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Table)Tj
2.4435 0 Td
(4)Tj
0 g
0.6916 0 Td
(and)Tj
1.7291 0 Td
(ref.)Tj
1.5307 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(]\).)Tj
2.4151 0 Td
(For)Tj
1.6271 0 Td
(all)Tj
1.1452 0 Td
(algorithms,)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 703.8918 m
575.9997 703.8918 l
575.9997 703.3918 l
35.9997 703.3918 l
f*
113.6568 703.3918 m
113.6568 690.8919 l
113.1568 690.8919 l
113.1568 703.3918 l
f*
113.1568 690.8919 m
35.9997 690.8919 l
35.9997 691.3919 l
113.1568 691.3919 l
f*
309.1088 703.3918 m
309.1088 690.8919 l
308.6087 690.8919 l
308.6087 703.3918 l
f*
308.6087 690.8919 m
113.6568 690.8919 l
113.6568 691.3919 l
308.6087 691.3919 l
f*
387.2738 703.3918 m
387.2738 690.8919 l
386.7738 690.8919 l
386.7738 703.3918 l
f*
386.7738 690.8919 m
309.1088 690.8919 l
309.1088 691.3919 l
386.7738 691.3919 l
f*
480.8897 703.3918 m
480.8897 690.8919 l
480.3897 690.8919 l
480.3897 703.3918 l
f*
480.3897 690.8919 m
387.2738 690.8919 l
387.2738 691.3919 l
480.3897 691.3919 l
f*
575.9997 690.8919 m
480.8897 690.8919 l
480.8897 691.3919 l
575.9997 691.3919 l
f*
113.6568 690.8919 m
113.6568 678.3919 l
113.1568 678.3919 l
113.1568 690.8919 l
f*
113.1568 678.3919 m
35.9997 678.3919 l
35.9997 678.892 l
113.1568 678.892 l
f*
309.1088 690.8919 m
309.1088 678.3919 l
308.6087 678.3919 l
308.6087 690.8919 l
f*
308.6087 678.3919 m
113.6568 678.3919 l
113.6568 678.892 l
308.6087 678.892 l
f*
387.2738 690.8919 m
387.2738 678.3919 l
386.7738 678.3919 l
386.7738 690.8919 l
f*
386.7738 678.3919 m
309.1088 678.3919 l
309.1088 678.892 l
386.7738 678.892 l
f*
480.8897 690.8919 m
480.8897 678.3919 l
480.3897 678.3919 l
480.3897 690.8919 l
f*
480.3897 678.3919 m
387.2738 678.3919 l
387.2738 678.892 l
480.3897 678.892 l
f*
575.9997 678.3919 m
480.8897 678.3919 l
480.8897 678.892 l
575.9997 678.892 l
f*
113.6568 678.3919 m
113.6568 665.892 l
113.1568 665.892 l
113.1568 678.3919 l
f*
113.1568 665.892 m
35.9997 665.892 l
35.9997 666.392 l
113.1568 666.392 l
f*
309.1088 678.3919 m
309.1088 665.892 l
308.6087 665.892 l
308.6087 678.3919 l
f*
308.6087 665.892 m
113.6568 665.892 l
113.6568 666.392 l
308.6087 666.392 l
f*
387.2738 678.3919 m
387.2738 665.892 l
386.7738 665.892 l
386.7738 678.3919 l
f*
386.7738 665.892 m
309.1088 665.892 l
309.1088 666.392 l
386.7738 666.392 l
f*
480.8897 678.3919 m
480.8897 665.892 l
480.3897 665.892 l
480.3897 678.3919 l
f*
480.3897 665.892 m
387.2738 665.892 l
387.2738 666.392 l
480.3897 666.392 l
f*
575.9997 665.892 m
480.8897 665.892 l
480.8897 666.392 l
575.9997 666.392 l
f*
113.6568 665.892 m
113.6568 653.3921 l
113.1568 653.3921 l
113.1568 665.892 l
f*
113.1568 653.3921 m
35.9997 653.3921 l
35.9997 653.8921 l
113.1568 653.8921 l
f*
309.1088 665.892 m
309.1088 653.3921 l
308.6087 653.3921 l
308.6087 665.892 l
f*
308.6087 653.3921 m
113.6568 653.3921 l
113.6568 653.8921 l
308.6087 653.8921 l
f*
387.2738 665.892 m
387.2738 653.3921 l
386.7738 653.3921 l
386.7738 665.892 l
f*
386.7738 653.3921 m
309.1088 653.3921 l
309.1088 653.8921 l
386.7738 653.8921 l
f*
480.8897 665.892 m
480.8897 653.3921 l
480.3897 653.3921 l
480.3897 665.892 l
f*
480.3897 653.3921 m
387.2738 653.3921 l
387.2738 653.8921 l
480.3897 653.8921 l
f*
575.9997 653.3921 m
480.8897 653.3921 l
480.8897 653.8921 l
575.9997 653.8921 l
f*
113.6568 653.3921 m
113.6568 640.8921 l
113.1568 640.8921 l
113.1568 653.3921 l
f*
113.1568 640.8921 m
35.9997 640.8921 l
35.9997 641.3922 l
113.1568 641.3922 l
f*
309.1088 653.3921 m
309.1088 640.8921 l
308.6087 640.8921 l
308.6087 653.3921 l
f*
308.6087 640.8921 m
113.6568 640.8921 l
113.6568 641.3922 l
308.6087 641.3922 l
f*
387.2738 653.3921 m
387.2738 640.8921 l
386.7738 640.8921 l
386.7738 653.3921 l
f*
386.7738 640.8921 m
309.1088 640.8921 l
309.1088 641.3922 l
386.7738 641.3922 l
f*
480.8897 653.3921 m
480.8897 640.8921 l
480.3897 640.8921 l
480.3897 653.3921 l
f*
480.3897 640.8921 m
387.2738 640.8921 l
387.2738 641.3922 l
480.3897 641.3922 l
f*
575.9997 640.8921 m
480.8897 640.8921 l
480.8897 641.3922 l
575.9997 641.3922 l
f*
113.6568 640.8921 m
113.6568 628.3922 l
113.1568 628.3922 l
113.1568 640.8921 l
f*
113.1568 628.3922 m
35.9997 628.3922 l
35.9997 628.8922 l
113.1568 628.8922 l
f*
309.1088 640.8921 m
309.1088 628.3922 l
308.6087 628.3922 l
308.6087 640.8921 l
f*
308.6087 628.3922 m
113.6568 628.3922 l
113.6568 628.8922 l
308.6087 628.8922 l
f*
387.2738 640.8921 m
387.2738 628.3922 l
386.7738 628.3922 l
386.7738 640.8921 l
f*
386.7738 628.3922 m
309.1088 628.3922 l
309.1088 628.8922 l
386.7738 628.8922 l
f*
480.8897 640.8921 m
480.8897 628.3922 l
480.3897 628.3922 l
480.3897 640.8921 l
f*
480.3897 628.3922 m
387.2738 628.3922 l
387.2738 628.8922 l
480.3897 628.8922 l
f*
575.9997 628.3922 m
480.8897 628.3922 l
480.8897 628.8922 l
575.9997 628.8922 l
f*
113.6568 628.3922 m
113.6568 615.8923 l
113.1568 615.8923 l
113.1568 628.3922 l
f*
113.1568 615.8923 m
35.9997 615.8923 l
35.9997 616.3923 l
113.1568 616.3923 l
f*
309.1088 628.3922 m
309.1088 615.8923 l
308.6087 615.8923 l
308.6087 628.3922 l
f*
308.6087 615.8923 m
113.6568 615.8923 l
113.6568 616.3923 l
308.6087 616.3923 l
f*
387.2738 628.3922 m
387.2738 615.8923 l
386.7738 615.8923 l
386.7738 628.3922 l
f*
386.7738 615.8923 m
309.1088 615.8923 l
309.1088 616.3923 l
386.7738 616.3923 l
f*
480.8897 628.3922 m
480.8897 615.8923 l
480.3897 615.8923 l
480.3897 628.3922 l
f*
480.3897 615.8923 m
387.2738 615.8923 l
387.2738 616.3923 l
480.3897 616.3923 l
f*
575.9997 615.8923 m
480.8897 615.8923 l
480.8897 616.3923 l
575.9997 616.3923 l
f*
113.6568 615.8923 m
113.6568 603.3923 l
113.1568 603.3923 l
113.1568 615.8923 l
f*
113.1568 603.3923 m
35.9997 603.3923 l
35.9997 603.8923 l
113.1568 603.8923 l
f*
309.1088 615.8923 m
309.1088 603.3923 l
308.6087 603.3923 l
308.6087 615.8923 l
f*
308.6087 603.3923 m
113.6568 603.3923 l
113.6568 603.8923 l
308.6087 603.8923 l
f*
387.2738 615.8923 m
387.2738 603.3923 l
386.7738 603.3923 l
386.7738 615.8923 l
f*
386.7738 603.3923 m
309.1088 603.3923 l
309.1088 603.8923 l
386.7738 603.8923 l
f*
480.8897 615.8923 m
480.8897 603.3923 l
480.3897 603.3923 l
480.3897 615.8923 l
f*
480.3897 603.3923 m
387.2738 603.3923 l
387.2738 603.8923 l
480.3897 603.8923 l
f*
575.9997 603.3923 m
480.8897 603.3923 l
480.8897 603.8923 l
575.9997 603.8923 l
f*
113.6568 603.3923 m
113.6568 590.8924 l
113.1568 590.8924 l
113.1568 603.3923 l
f*
113.1568 590.8924 m
35.9997 590.8924 l
35.9997 591.3924 l
113.1568 591.3924 l
f*
309.1088 603.3923 m
309.1088 590.8924 l
308.6087 590.8924 l
308.6087 603.3923 l
f*
308.6087 590.8924 m
113.6568 590.8924 l
113.6568 591.3924 l
308.6087 591.3924 l
f*
387.2738 603.3923 m
387.2738 590.8924 l
386.7738 590.8924 l
386.7738 603.3923 l
f*
386.7738 590.8924 m
309.1088 590.8924 l
309.1088 591.3924 l
386.7738 591.3924 l
f*
480.8897 603.3923 m
480.8897 590.8924 l
480.3897 590.8924 l
480.3897 603.3923 l
f*
480.3897 590.8924 m
387.2738 590.8924 l
387.2738 591.3924 l
480.3897 591.3924 l
f*
575.9997 590.8924 m
480.8897 590.8924 l
480.8897 591.3924 l
575.9997 591.3924 l
f*
113.6568 590.8924 m
113.6568 578.3924 l
113.1568 578.3924 l
113.1568 590.8924 l
f*
113.1568 578.3924 m
35.9997 578.3924 l
35.9997 578.8925 l
113.1568 578.8925 l
f*
309.1088 590.8924 m
309.1088 578.3924 l
308.6087 578.3924 l
308.6087 590.8924 l
f*
308.6087 578.3924 m
113.6568 578.3924 l
113.6568 578.8925 l
308.6087 578.8925 l
f*
387.2738 590.8924 m
387.2738 578.3924 l
386.7738 578.3924 l
386.7738 590.8924 l
f*
386.7738 578.3924 m
309.1088 578.3924 l
309.1088 578.8925 l
386.7738 578.8925 l
f*
480.8897 590.8924 m
480.8897 578.3924 l
480.3897 578.3924 l
480.3897 590.8924 l
f*
480.3897 578.3924 m
387.2738 578.3924 l
387.2738 578.8925 l
480.3897 578.8925 l
f*
575.9997 578.3924 m
480.8897 578.3924 l
480.8897 578.8925 l
575.9997 578.8925 l
f*
113.6568 578.3924 m
113.6568 565.8925 l
113.1568 565.8925 l
113.1568 578.3924 l
f*
113.1568 565.8925 m
35.9997 565.8925 l
35.9997 566.3925 l
113.1568 566.3925 l
f*
309.1088 578.3924 m
309.1088 565.8925 l
308.6087 565.8925 l
308.6087 578.3924 l
f*
308.6087 565.8925 m
113.6568 565.8925 l
113.6568 566.3925 l
308.6087 566.3925 l
f*
387.2738 578.3924 m
387.2738 565.8925 l
386.7738 565.8925 l
386.7738 578.3924 l
f*
386.7738 565.8925 m
309.1088 565.8925 l
309.1088 566.3925 l
386.7738 566.3925 l
f*
480.8897 578.3924 m
480.8897 565.8925 l
480.3897 565.8925 l
480.3897 578.3924 l
f*
480.3897 565.8925 m
387.2738 565.8925 l
387.2738 566.3925 l
480.3897 566.3925 l
f*
575.9997 565.8925 m
480.8897 565.8925 l
480.8897 566.3925 l
575.9997 566.3925 l
f*
0.83 0.64 0.02 0 k
345.5433 680.315 m
353.1969 680.315 l
h
f*
345.5433 617.8394 m
353.1969 617.8394 l
h
f*
345.5433 605.3102 m
353.1969 605.3102 l
h
f*
36 552.8126 m
184.5354 552.8126 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(2.)Tj
0.9567 0 Td
(Overview)Tj
4.1386 0 Td
(over)Tj
2.0268 0 Td
(submitted)Tj
4.4433 0 Td
(algorithm)Tj
4.1386 0 Td
(s)Tj
0.6024 0 Td
(and)Tj
1.7787 0 Td
(key)Tj
1.6158 0 Td
(properties.)Tj
0 Tc
-18.808 -1.8567 Td
(Team)Tj
6.5126 0 Td
(Contributo)Tj
4.7339 0 Td
(rs)Tj
23.2656 0 Td
(new?)Tj
6.2008 0 Td
(Language)Tj
11.7072 0 Td
(Type)Tj
/F6 1 Tf
-51.4705 -1.559 Td
(1)Tj
5.6906 0 Td
(T.)Tj
1.0701 0 Td
(Deneux)Tj
26.8443 0 Td
(-[)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
6.2859 0 Td
(Matlab)Tj
11.7 0 Td
(generative)Tj
-51.5909 -1.5591 Td
(2)Tj
5.6906 0 Td
(N.)Tj
1.1905 0 Td
(Chenkov,)Tj
4.0961 0 Td
(T.)Tj
1.0701 0 Td
(McColgan)Tj
22.2593 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.5661 Td
(3)Tj
5.6906 0 Td
(A.)Tj
1.1409 0 Td
(Speiser,)Tj
3.3166 0 Td
(J.)Tj
0.7866 0 Td
(Macke,)Tj
3.1394 0 Td
(S.)Tj
0.9355 0 Td
(Turaga)Tj
19.297 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.5591 Td
(4)Tj
5.6906 0 Td
(P.)Tj
1.0205 0 Td
(Mineault)Tj
27.5955 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.5662 Td
(5)Tj
5.6906 0 Td
(P.)Tj
1.0205 0 Td
(Ruppr)Tj
2.5582 0 Td
(echt,)Tj
2.1473 0 Td
(S.)Tj
0.9355 0 Td
(Gerhard)Tj
3.3803 0 Td
(,)Tj
0.4606 0 Td
(R.)Tj
1.0843 0 Td
(W.)Tj
1.4244 0 Td
(Friedrich)Tj
15.6049 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.559 Td
(6)Tj
5.6906 0 Td
(J.)Tj
0.7866 0 Td
(Friedrich,)Tj
4.1882 0 Td
(L.)Tj
0.9992 0 Td
(Paninski)Tj
21.9404 0 Td
(-[)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
6.2859 0 Td
(Python)Tj
11.7 0 Td
(generative)Tj
-51.5909 -1.5662 Td
(7)Tj
5.6906 0 Td
(M.)Tj
1.3464 0 Td
(Pachitariu)Tj
26.568 0 Td
(-[)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(])Tj
6.2859 0 Td
(Matlab)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.5591 Td
(8)Tj
5.6906 0 Td
(B.)Tj
1.0346 0 Td
(Bolte)Tj
27.5814 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(supervised)Tj
-51.5909 -1.5661 Td
(9)Tj
5.6906 0 Td
(T.)Tj
1.0701 0 Td
(Machad)Tj
3.2457 0 Td
(o,)Tj
0.9708 0 Td
(L.)Tj
0.9993 0 Td
(Paninski)Tj
22.3301 0 Td
(+)Tj
5.5843 0 Td
(Python)Tj
11.7 0 Td
(generative)Tj
-51.8248 -1.5591 Td
(10)Tj
5.9245 0 Td
(D.)Tj
1.1905 0 Td
(Ringach)Tj
27.4255 0 Td
(+)Tj
5.5843 0 Td
(Matlab)Tj
11.7 0 Td
(supervised)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.025 Tc
-55.9846 -1.8779 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pc)Tj
3.4583 0 Td
(bi.1006157.)Tj
4.4292 0 Td
(t002)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 169.8814 m
575.9997 169.8814 l
575.9997 169.3814 l
35.9997 169.3814 l
f*
105.3703 169.3814 m
105.3703 156.8815 l
104.8703 156.8815 l
104.8703 169.3814 l
f*
104.8703 156.8815 m
35.9997 156.8815 l
35.9997 157.3815 l
104.8703 157.3815 l
f*
204.2654 169.3814 m
204.2654 156.8815 l
203.7654 156.8815 l
203.7654 169.3814 l
f*
203.7654 156.8815 m
105.3703 156.8815 l
105.3703 157.3815 l
203.7654 157.3815 l
f*
292.5023 169.3814 m
292.5023 156.8815 l
292.0022 156.8815 l
292.0022 169.3814 l
f*
292.0022 156.8815 m
204.2654 156.8815 l
204.2654 157.3815 l
292.0022 157.3815 l
f*
374.925 169.3814 m
374.925 156.8815 l
374.4249 156.8815 l
374.4249 169.3814 l
f*
374.4249 156.8815 m
292.5023 156.8815 l
292.5023 157.3815 l
374.4249 157.3815 l
f*
472.3835 169.3814 m
472.3835 156.8815 l
471.8835 156.8815 l
471.8835 169.3814 l
f*
471.8835 156.8815 m
374.925 156.8815 l
374.925 157.3815 l
471.8835 157.3815 l
f*
575.9991 156.8815 m
472.3835 156.8815 l
472.3835 157.3815 l
575.9991 157.3815 l
f*
105.3703 156.8815 m
105.3703 144.3815 l
104.8703 144.3815 l
104.8703 156.8815 l
f*
104.8703 144.3815 m
35.9997 144.3815 l
35.9997 144.8816 l
104.8703 144.8816 l
f*
204.2654 156.8815 m
204.2654 144.3815 l
203.7654 144.3815 l
203.7654 156.8815 l
f*
203.7654 144.3815 m
105.3703 144.3815 l
105.3703 144.8816 l
203.7654 144.8816 l
f*
292.5023 156.8815 m
292.5023 144.3815 l
292.0022 144.3815 l
292.0022 156.8815 l
f*
292.0022 144.3815 m
204.2654 144.3815 l
204.2654 144.8816 l
292.0022 144.8816 l
f*
374.925 156.8815 m
374.925 144.3815 l
374.4249 144.3815 l
374.4249 156.8815 l
f*
374.4249 144.3815 m
292.5023 144.3815 l
292.5023 144.8816 l
374.4249 144.8816 l
f*
472.3835 156.8815 m
472.3835 144.3815 l
471.8835 144.3815 l
471.8835 156.8815 l
f*
471.8835 144.3815 m
374.925 144.3815 l
374.925 144.8816 l
471.8835 144.8816 l
f*
575.9991 144.3815 m
472.3835 144.3815 l
472.3835 144.8816 l
575.9991 144.8816 l
f*
105.3703 144.3815 m
105.3703 131.8816 l
104.8703 131.8816 l
104.8703 144.3815 l
f*
104.8703 131.8816 m
35.9997 131.8816 l
35.9997 132.3816 l
104.8703 132.3816 l
f*
204.2654 144.3815 m
204.2654 131.8816 l
203.7654 131.8816 l
203.7654 144.3815 l
f*
203.7654 131.8816 m
105.3703 131.8816 l
105.3703 132.3816 l
203.7654 132.3816 l
f*
292.5023 144.3815 m
292.5023 131.8816 l
292.0022 131.8816 l
292.0022 144.3815 l
f*
292.0022 131.8816 m
204.2654 131.8816 l
204.2654 132.3816 l
292.0022 132.3816 l
f*
374.925 144.3815 m
374.925 131.8816 l
374.4249 131.8816 l
374.4249 144.3815 l
f*
374.4249 131.8816 m
292.5023 131.8816 l
292.5023 132.3816 l
374.4249 132.3816 l
f*
472.3835 144.3815 m
472.3835 131.8816 l
471.8835 131.8816 l
471.8835 144.3815 l
f*
471.8835 131.8816 m
374.925 131.8816 l
374.925 132.3816 l
471.8835 132.3816 l
f*
575.9991 131.8816 m
472.3835 131.8816 l
472.3835 132.3816 l
575.9991 132.3816 l
f*
105.3703 131.8816 m
105.3703 119.3817 l
104.8703 119.3817 l
104.8703 131.8816 l
f*
104.8703 119.3817 m
35.9997 119.3817 l
35.9997 119.8817 l
104.8703 119.8817 l
f*
204.2654 131.8816 m
204.2654 119.3817 l
203.7654 119.3817 l
203.7654 131.8816 l
f*
203.7654 119.3817 m
105.3703 119.3817 l
105.3703 119.8817 l
203.7654 119.8817 l
f*
292.5023 131.8816 m
292.5023 119.3817 l
292.0022 119.3817 l
292.0022 131.8816 l
f*
292.0022 119.3817 m
204.2654 119.3817 l
204.2654 119.8817 l
292.0022 119.8817 l
f*
374.925 131.8816 m
374.925 119.3817 l
374.4249 119.3817 l
374.4249 131.8816 l
f*
374.4249 119.3817 m
292.5023 119.3817 l
292.5023 119.8817 l
374.4249 119.8817 l
f*
472.3835 131.8816 m
472.3835 119.3817 l
471.8835 119.3817 l
471.8835 131.8816 l
f*
471.8835 119.3817 m
374.925 119.3817 l
374.925 119.8817 l
471.8835 119.8817 l
f*
575.9991 119.3817 m
472.3835 119.3817 l
472.3835 119.8817 l
575.9991 119.8817 l
f*
105.3703 119.3817 m
105.3703 106.8817 l
104.8703 106.8817 l
104.8703 119.3817 l
f*
104.8703 106.8817 m
35.9997 106.8817 l
35.9997 107.3818 l
104.8703 107.3818 l
f*
204.2654 119.3817 m
204.2654 106.8817 l
203.7654 106.8817 l
203.7654 119.3817 l
f*
203.7654 106.8817 m
105.3703 106.8817 l
105.3703 107.3818 l
203.7654 107.3818 l
f*
292.5023 119.3817 m
292.5023 106.8817 l
292.0022 106.8817 l
292.0022 119.3817 l
f*
292.0022 106.8817 m
204.2654 106.8817 l
204.2654 107.3818 l
292.0022 107.3818 l
f*
374.925 119.3817 m
374.925 106.8817 l
374.4249 106.8817 l
374.4249 119.3817 l
f*
374.4249 106.8817 m
292.5023 106.8817 l
292.5023 107.3818 l
374.4249 107.3818 l
f*
472.3835 119.3817 m
472.3835 106.8817 l
471.8835 106.8817 l
471.8835 119.3817 l
f*
471.8835 106.8817 m
374.925 106.8817 l
374.925 107.3818 l
471.8835 107.3818 l
f*
575.9991 106.8817 m
472.3835 106.8817 l
472.3835 107.3818 l
575.9991 107.3818 l
f*
105.3703 106.8817 m
105.3703 94.3818 l
104.8703 94.3818 l
104.8703 106.8817 l
f*
104.8703 94.3818 m
35.9997 94.3818 l
35.9997 94.8818 l
104.8703 94.8818 l
f*
204.2654 106.8817 m
204.2654 94.3818 l
203.7654 94.3818 l
203.7654 106.8817 l
f*
203.7654 94.3818 m
105.3703 94.3818 l
105.3703 94.8818 l
203.7654 94.8818 l
f*
292.5023 106.8817 m
292.5023 94.3818 l
292.0022 94.3818 l
292.0022 106.8817 l
f*
292.0022 94.3818 m
204.2654 94.3818 l
204.2654 94.8818 l
292.0022 94.8818 l
f*
374.925 106.8817 m
374.925 94.3818 l
374.4249 94.3818 l
374.4249 106.8817 l
f*
374.4249 94.3818 m
292.5023 94.3818 l
292.5023 94.8818 l
374.4249 94.8818 l
f*
472.3835 106.8817 m
472.3835 94.3818 l
471.8835 94.3818 l
471.8835 106.8817 l
f*
471.8835 94.3818 m
374.925 94.3818 l
374.925 94.8818 l
471.8835 94.8818 l
f*
575.9991 94.3818 m
472.3835 94.3818 l
472.3835 94.8818 l
575.9991 94.8818 l
f*
0.83 0.64 0.02 0 k
36 81.2976 m
184.5354 81.2976 l
h
f*
0 g
7.9999 0 0 7.9999 36 193.7196 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(3.)Tj
0.9567 0 Td
(Overview)Tj
4.1386 0 Td
(over)Tj
2.0268 0 Td
(different)Tj
3.8622 0 Td
(strategies)Tj
4.1457 0 Td
(used)Tj
2.1189 0 Td
(by)Tj
1.2118 0 Td
(DNN-ba)Tj
3.5363 0 Td
(sed)Tj
1.5803 0 Td
(algorithm)Tj
4.1386 0 Td
(s.)Tj
/F6 1 Tf
0.8433 0 Td
(Architectu)Tj
4.2166 0 Td
(re)Tj
1.0134 0 Td
(briefly)Tj
2.7567 0 Td
(summarize)Tj
4.4079 0 Td
(s)Tj
0.5811 0 Td
(main)Tj
2.2748 0 Td
(component)Tj
4.5639 0 Td
(s.)Tj
0.8078 0 Td
(conv:)Tj
2.3599 0 Td
(convolution)Tj
4.8048 0 Td
(al)Tj
0.9 0 Td
(layers,)Tj
2.7142 0 Td
(typically)Tj
-62.5115 -1.1905 Td
(with)Tj
1.9842 0 Td
(non-linear)Tj
4.2166 0 Td
(ity;)Tj
1.4598 0 Td
(lstm:)Tj
2.1544 0 Td
(recurrent)Tj
3.9543 0 Td
(long-short-te)Tj
5.2229 0 Td
(rm)Tj
1.4032 0 Td
(memory)Tj
3.6 0 Td
(unit;)Tj
2.0693 0 Td
(residual:)Tj
3.5859 0 Td
(residual)Tj
3.352 0 Td
(blocks;)Tj
2.9693 0 Td
(max:)Tj
2.1543 0 Td
(max-pool)Tj
3.8197 0 Td
(ing)Tj
1.4953 0 Td
(layers;)Tj
2.7213 0 Td
(incepti)Tj
2.7213 0 Td
(on:)Tj
1.4953 0 Td
(inception)Tj
3.9969 0 Td
(cells.)Tj
2.1331 0 Td
(For)Tj
1.6157 0 Td
(details,)Tj
2.9835 0 Td
(refer)Tj
2.0835 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
-64.2123 -1.1835 Td
(descriptions)Tj
5.0598 0 Td
(of)Tj
1.0134 0 Td
(the)Tj
1.4599 0 Td
(algorithms)Tj
4.4858 0 Td
(in)Tj
1.0347 0 Td
(the)Tj
1.4599 0 Td
(supplementar)Tj
5.4567 0 Td
(y)Tj
0.6661 0 Td
(material.)Tj
/F12 1 Tf
0 Tc
-17.7166 -1.8567 Td
(Team)Tj
9.241 0 Td
(Architecture)Tj
12.1678 0 Td
(Optimizer)Tj
11.0339 0 Td
(Dropout)Tj
12.1041 0 Td
(Cost)Tj
10.3819 0 Td
(dataset)Tj
3.2174 0 Td
(specific)Tj
/F6 1 Tf
-57.1894 -1.5591 Td
(2)Tj
8.7095 0 Td
(conv)Tj
2.1756 0 Td
(/)Tj
0.5598 0 Td
(lstm)Tj
9.9568 0 Td
(Adam)Tj
11.282 0 Td
(yes)Tj
9.652 0 Td
(correlation)Tj
12.9828 0 Td
(indicator)Tj
-55.3185 -1.5661 Td
(3)Tj
8.6599 0 Td
(RNN/CNN)Tj
12.7418 0 Td
(Adam)Tj
20.3884 0 Td
(cross-en)Tj
3.359 0 Td
(tropy)Tj
10.3607 0 Td
(separate)Tj
-55.5098 -1.5591 Td
(4)Tj
8.0929 0 Td
(residual)Tj
3.4087 0 Td
(/)Tj
0.5599 0 Td
(lstm)Tj
9.3402 0 Td
(Adam)Tj
11.282 0 Td
(yes)Tj
9.7725 0 Td
(scaled)Tj
2.6575 0 Td
(SSE)Tj
10.4741 0 Td
(transfer)Tj
-55.5878 -1.5661 Td
(5)Tj
8.7166 0 Td
(conv)Tj
2.1685 0 Td
(/)Tj
0.5669 0 Td
(max)Tj
9.4607 0 Td
(Adagrad)Tj
11.8631 0 Td
(no)Tj
10.8001 0 Td
(MSE)Tj
11.3103 0 Td
(embedding)Tj
-54.8862 -1.5591 Td
(8)Tj
9.0355 0 Td
(inceptio)Tj
3.2669 0 Td
(n)Tj
9.0993 0 Td
(Adam)Tj
11.282 0 Td
(yes)Tj
9.652 0 Td
(correlation)Tj
12.5505 0 Td
(embedding)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.025 Tc
-58.7626 -1.878 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pc)Tj
3.4583 0 Td
(bi.1006157.)Tj
4.4292 0 Td
(t003)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 347.0173 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Benchmar)Tj
4.4858 0 Td
(king)Tj
2.0197 0 Td
(spike)Tj
2.5087 0 Td
(rate)Tj
1.9134 0 Td
(inference)Tj
4.2591 0 Td
(for)Tj
1.3677 0 Td
(two-photo)Tj
4.3158 0 Td
(n)Tj
0.7654 0 Td
(calcium)Tj
3.5504 0 Td
(imaging)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006157)Tj
0 g
6.3497 0 Td
(May)Tj
2.0835 0 Td
(21,)Tj
1.5874 0 Td
(2018)Tj
27.9923 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
endstream
endobj
117 0 obj
<>stream
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
126 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 129 0 R/Contents 130 0 R/TrimBox[0 0 612 792]>>
endobj
128 0 obj
<>stream
xi^yoi8@x4@ |H̄
;$8DA)EfdIBTdbQ%jͲ+N˕H&))?Sog9:ujy_>>T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
P*@ T
de~N:cƌ۷/ӱ,*@ T
P*@ T
P*@ hK.?&MZxqGO T
P*@ T
P*@ T ;j׆|O2ĉٍQ*@ T
P*@ T
P*@@\_cӑVR*@ T
P*@ T
P*@@v
uvAT
P*@ T
P*@ T
P*j`|]c{柖R*@ T
P*@ T
P*@S\#?3{ɓ'SNn4
P*@ T
P*@ T
P*@Z Kcu'MSe T
P*@ T
P*@ T
Thmʔ)^vv*@ T
P*{8>>i'T
P*@ hŋ ۾h?T
P*@V
8qBd
P*@ T
P/䒆eT
P*@ Ti.2ol2{gT
P*@ T
@/yO)7mbT
P*@ T +WD饗fe-T
P*@ ]U"{]4rׇ~?Li{9w&kXh?
`m>|xǏLS+駟bm͵3fp[{yDٳgs6=zLS:9@*"qU8p ex@09s
|ڇ7iFT_%40_#%dl ٓ}laT`X`7 Y9x;yqK kKO!\twl
xz x%bf
hJcTU
?2nkL:5^UKrKg&R4k YE*ns
y\kmYDnO9\CFbTHa~2HiI͎Er#OIH*ġ2̔UZ ^+FPkh@_0_ј`.y"Eَwl H o\#WfS@]|M%s[b %M_nRB@VV,iqsNFUk{XX>kH%BD"T?
&Пv4NM#ҋ{G joF@7 #s*}sa%?G
$S gg>Pb#{Xixa?aGmW ڛ5i 4i{hL3dVitf/T [xvjc)M:ۑ\[xL!x۪hNcZ`%zea&=/]z~+6R K|<_%*U nק`|Ec'J3{*@SHi3َgƣ5bI o\ T
=kkYC%_C
ۮ vaj.]DzSOf@dvArV7g'ds&5Y {FXX-Q`
P5uikܸX
2ydaƩ%ҁ0;#}G)QD2
ti6[:RN\&&r̙)S^UWMJa8b,OګΙ?GpMp.`,lnmkkE^ܷoŋ-ٜrk0TiVTfD1N>8b
[O;]w\Ϛ5xT
+q X~Vスhڻ{:#PY`hcܪ8wc/qs|J\[NP{C5Uᱱ%Z7uVSCc@{gpF;.tU/Ʈxfvt)GSk.,B2W^p
, &v-Z'ޜ}n|~4؞16Ʒ0/\T-dLΆelj-6;\H><6ԣ
f@?{wF;.tRk{7 )Th!7xDq'*P#ST4I-ZgΟ*ZUֽ$]ݐa.HpsÞӠ-;?Xmh*;,uip
Fk06.䖗Έ6#my*0 *mw\rq
h8Ӣ|Q^1u&RV+P#>ydK&jgcaަat]"q9;pEbih7ڬ pkI
{f`7mKh^Mwݥ -}"hiU4l6YMVtT){Ŋ\w`kBIpևW(/z]Y h2iX/~AN ]ŘC@
bg"(3F@|fȃ}+n MFGc{X^@EA7vsX`XҠM\W1"ZU[]k^:kluK@>
Ԏ
G`ELp=k:Qg5`E?EUիWk :d/T
5뢈beU-F|G=5kx>s$$ꞗl.ЮRQ]SjIG\-0^i"z$nuwߞX*d( P=pGN7#HJP.T =nBUv1/r2zLH}M#_+]vU&|xgd5virkMWܼeiv؎V!;CD_OrxI$xףPcj0_Q8œn*TAETS h"I/j_dbZ(f/^ZVJ|/GpMp~.lTmbN^^%\Ϛ5K"'\wi9*5k-"@;gmp+;5vo!MI5;Yڜ^k?/݇z*kD
qQ&a^ -`Q5KV!=Gk0n`Sg|쭽sɰj)@p-w* DҶuOK/M$oMg.SM觪(v63;5Y$7
nr$?٣b9;Y+^|/GpMp.U_1&O\uvp6\YJˬ:9*`)Z7a>=ˊcnށa6/,*·ĘT"cG "D__]u
5j\ُkg5ҦP-d.Z(Z`2xm8wM\-Xa1Ma"Bçqx̰rg(0unUH](X:<$@18t4.! 8Z*[mӠu HnG?YU^ZT~GE=jP` \\U_%^XFŶo3J0Y
t[7 uNxO:mx؎W͙i^~7,gn6r3ƈЦ.0o8*ܘ;77c>tlpoǿ~x fa[
ck6 8qv\M!&(4;̶kS'?xa|:&u/L}7\ym41a GWGkWZt#6μ:2iw$$wg Kg~28_H$ S5Dy`[wYkM04@fLt
vW?WȌ3#LMa[GE1̬Qh0GpMp.ӧpuNk[[t~c/X{Zi(7fV<@olez[P%B ~&nށw(gXj
~ o#Lx7X>yM]ZMZxkJ5g k{$ l&覙6`e4敎KIfHpݪ\]kah<aY]}"~={{$.#!`t2cˮAu-UzX\^HfK-lJyGm6 3Xt(88ۈdNݵɳH4C@:TXע*4ydNjƪ?~ԿL_??gb+Io9õ
w'79n:qG$F_ZǟH Y/'I^[8lh(t1JxwF\Wo]as2;(@pB [
t)@+ZX4 bKF6ZhL:*Z6u*[6@V7pO{>rbV(79CKOtքjT`T
`/_={?z5 c`Vo"\ 0+ށ)6v.m:?AjIPXN h1 ܋W F.FOnvuݾw~.$ku1$aH$FP)rLZS~yz9Ikjdc/9E~dbMB]]K>bI##KF롸wup-1lHLtTтL: .t3iZGEwDI@p܇"]n\
ӝ~F6i7'NpAv.P2oYB: N e&SjO77pj}iXwaI*6[ xR2}laAWǦ7Q[uko3 ~hw-º (4~{b-uk6]?c(s^p
jΑ~<Gxw0ǫ Wfj,A u;ӑ
l*0v^:o4XVmB̶i] blRڊ|T/ѯ+fc uXN^9Þ%O`n+aoFJ^ⷮVXP)Jv5Ĝ(P#p